Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome

被引:55
作者
Barandouzi, Zahra A. [1 ,2 ]
Lee, Joochul [3 ,4 ]
Rosas, Maria Del Carmen [1 ]
Chen, Jie [1 ,5 ]
Henderson, Wendy A. [1 ]
Starkweather, Angela R. [1 ]
Cong, Xiaomei S. [1 ,6 ]
机构
[1] Univ Connecticut, Sch Nursing, 231 Glenbrook Rd,Unit 4026, Storrs, CT 06269 USA
[2] Emory Univ, Sch Nursing, 1520 Clifton Rd, Atlanta, GA 30322 USA
[3] Univ Connecticut, Dept Stat, 215 Glenbrook Rd,U-4120, Storrs, CT 06269 USA
[4] Univ Penn, Dept Biostat & Epidemiol, 423 Guardian Dr, Philadelphia, PA 19104 USA
[5] Univ Maryland, Sch Nursing, 655 W Lombard St, Baltimore, MD 21201 USA
[6] Univ Connecticut, Sch Nursing, Biobehav Res Lab, 231 Glenbrook Rd,Unit 4026, Storrs, CT 06269 USA
基金
美国国家卫生研究院;
关键词
ESCHERICHIA-COLI; BIOGENIC-AMINES; BACTERIA; ANXIETY; DEPRESSION; GROWTH;
D O I
10.1038/s41598-022-05756-0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Evidence highlights the comorbidity between emotional distress and irritable bowel syndrome (IBS) through the gut-brain axis. However, the underlying mechanism is largely unknown. Thus, the present study aimed to evaluate the associations among neurotransmitter levels and the gut microbiome profiles in persons with IBS and emotional distress. In this nested case-controlled study, emotional symptoms, including anxiety and depressive symptoms, were evaluated in 40 persons with IBS and 20 healthy controls (HC). Plasma neurotransmitters levels (serotonin and norepinephrine) and the gut microbiome profile of the collected fecal samples were examined. Emotional distress and microbiome profile were significantly different between IBS and HC groups. Lower but not significant neurotransmitters' levels (serotonin and norepinephrine) were observed in the IBS group compared to the HC. A negative correlation was found between norepinephrine levels and alpha diversity (Shannon and Simpson indices) in the IBS group. Moreover, serotonin levels were positively associated with the abundance of Proteobacteria, and norepinephrine were positively correlated with Bacteroidetes, but negatively associated with Firmicutes phylum. The present study demonstrated alteration in the gut microbiome between persons with IBS and emotional distress compared to HC. The correlations between plasma neurotransmitters and the gut microbiome suggest that the gut microbiome may impact the regulation of neurotransmitters.
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页数:11
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