Rapid membrane protein topology prediction

被引：43

作者：

Hennerdal, Aron ^{[1
]}

Elofsson, Arne ^{[1
]}

机构：

[1] Stockholm Univ, Dept Biochem & Biophys, Stockholm Bioinformat Ctr, Ctr Biomembrane Res,Swedish E Sci Res Ctr, S-10691 Stockholm, Sweden

来源：

BIOINFORMATICS | 2011年 / 27卷 / 09期

基金：

瑞典研究理事会;

关键词：

TRANSMEMBRANE TOPOLOGY; MODEL;

D O I：

10.1093/bioinformatics/btr119

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

State-of-the-art methods for topology of alpha-helical membrane proteins are based on the use of time-consuming multiple sequence alignments obtained from PSI-BLAST or other sources. Here, we examine if it is possible to use the consensus of topology prediction methods that are based on single sequences to obtain a similar accuracy as the more accurate multiple sequence-based methods. Here, we show that TOPCONS-single performs better than any of the other topology prediction methods tested here, but similar to 6% worse than the best method that is utilizing multiple sequence alignments.

引用

页码：1322 / 1323

页数：2