Cholesteryl Ester Transfer Protein: The Controversial Relation to Atherosclerosis and Emerging New Biological Roles

被引：39
作者：
Oliveira, Helena C. F. [1 ]
de Faria, Eliana C. [2 ]
机构：
[1] Univ Estadual Campinas, Inst Biol, Dept Physiol & Biophys, BR-13083862 Campinas, SP, Brazil
[2] Univ Estadual Campinas, Dept Clin Pathol, BR-13083862 Campinas, SP, Brazil
来源：
IUBMB LIFE | 2011年 / 63卷 / 04期
基金：
巴西圣保罗研究基金会;
关键词：
CETP; atherosclerosis; Alzheimer disease; inflammation; obesity; CORONARY-HEART-DISEASE; CETP MESSENGER-RNA; DENSITY-LIPOPROTEIN-CHOLESTEROL; ONSET ALZHEIMERS-DISEASE; LIPID TRANSFER PROTEIN; TRANSGENIC MICE; ADIPOSE-TISSUE; LDL RECEPTOR; ATTENUATES ATHEROSCLEROSIS; SCAVENGER RECEPTOR;
D O I：
10.1002/iub.448
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cholesteryl ester transfer protein (CETP) exerts a profound impact on high-density lipoprotein (HDL) metabolism and, consequently, on the risk of atherosclerosis development and cardiovascular mortality. Here, we review the complex relationship between CETP and atherosclerosis based upon the experimental, clinical, and epidemiological studies. In addition, we discuss the recent findings that expand the functions of CETP to new areas of interest such as Alzheimer's disease, inflammation, and obesity. (C) 2011 IUBMB IUBMB Life, 63(4): 248-257, 2011
引用
收藏
页码：248 / 257
页数：10
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