The Expression of MGMT and ErbB2 in Human Glioma

被引：0

作者：

Sun Chun-ming ^{[1
]}

Wang Zhi-min ^{[1
]}

Zheng Shi-ying ^{[2
]}

Xu Qi-nian ^{[1
]}

Zhang Shi-ming ^{[1
]}

Zhou Dai ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Hosp 1, Dept Neurosurg, Suzhou 215006, Peoples R China

[2] Soochow Univ, Affiliated Hosp 1, Dept Cardio Thorac Surg, Suzhou 215006, Peoples R China

来源：

2009 INTERNATIONAL CONFERENCE ON FUTURE BIOMEDICAL INFORMATION ENGINEERING (FBIE 2009) | 2009年

关键词：

Glioma: Drug-resistance gene: RT-PCR; O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE; BREAST-CANCER; METHYLTRANSFERASE; CHEMOTHERAPY; CELLS; O-6-BENZYLGUANINE; RESISTANCE;

D O I：

10.1109/FBIE.2009.5405896

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This study was comparison of MGMT and ERBB2 expression in human gliomas. RT-PCR method was used to determine the mRNA levels of MGMT and ErbB2 gene in 42 clinical glioma specimens,There was significant concordance between the expression of MGMT and ErbB2(p<0.01). MGMT and ErbB are highly remarkably related each other. The results suggest that there may be in relationship among MGMT and ErbB2 expression in human gliomas which affect DNA repair resulting in drug resistance.

引用

页码：253 / +

页数：2

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