The Expression of MGMT and ErbB2 in Human Glioma

被引：0

作者：

Sun Chun-ming ^{[1
]}

Wang Zhi-min ^{[1
]}

Zheng Shi-ying ^{[2
]}

Xu Qi-nian ^{[1
]}

Zhang Shi-ming ^{[1
]}

Zhou Dai ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Hosp 1, Dept Neurosurg, Suzhou 215006, Peoples R China

[2] Soochow Univ, Affiliated Hosp 1, Dept Cardio Thorac Surg, Suzhou 215006, Peoples R China

来源：

2009 INTERNATIONAL CONFERENCE ON FUTURE BIOMEDICAL INFORMATION ENGINEERING (FBIE 2009) | 2009年

关键词：

Glioma: Drug-resistance gene: RT-PCR; O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE; BREAST-CANCER; METHYLTRANSFERASE; CHEMOTHERAPY; CELLS; O-6-BENZYLGUANINE; RESISTANCE;

D O I：

10.1109/FBIE.2009.5405896

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This study was comparison of MGMT and ERBB2 expression in human gliomas. RT-PCR method was used to determine the mRNA levels of MGMT and ErbB2 gene in 42 clinical glioma specimens,There was significant concordance between the expression of MGMT and ErbB2(p<0.01). MGMT and ErbB are highly remarkably related each other. The results suggest that there may be in relationship among MGMT and ErbB2 expression in human gliomas which affect DNA repair resulting in drug resistance.

引用

页码：253 / +

页数：2

共 50 条

[11] Activating mutations in ERBB2 and their diagnostics and treatment
Herter-Sprie, Grit S.
Greulich, Heidi
Wong, Kwok-Kin
FRONTIERS IN ONCOLOGY, 2013, 3
[12] A novel ErbB2 epitope targeted by human antitumor immunoagents
Troise, Fulvia
Monti, Maria
Merlino, Antonello
Cozzolino, Flora
Fedele, Carmine
Russo Krauss, Irene
Sica, Filomena
Pucci, Piero
D'Alessio, Giuseppe
De Lorenzo, Claudia
FEBS JOURNAL, 2011, 278 (07) : 1156 - 1166
[13] Gankyrin is frequently overexpressed in breast cancer and is associated with ErbB2 expression
Kim, Yeong Hwa
Kim, Jang-Hee
Choi, Yong Won
Lim, Seo Kyung
Yim, Hyunee
Kang, Seok Yun
Chung, Yong Sik
Lee, Ga-Young
Park, Tae Jun
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2013, 94 (02) : 360 - 365
[14] Identification and validation of an ERBB2 gene expression signature in breast cancers
François Bertucci
Nathalie Borie
Christophe Ginestier
Agnès Groulet
Emmanuelle Charafe-Jauffret
José Adélaïde
Jeannine Geneix
Loïc Bachelart
Pascal Finetti
Alane Koki
Fabienne Hermitte
Jacques Hassoun
Stéphane Debono
Patrice Viens
Vincent Fert
Jocelyne Jacquemier
Daniel Birnbaum
Oncogene, 2004, 23 : 2564 - 2575
[15] Identification and validation of an ERBB2 gene expression signature in breast cancers
Bertucci, F
Borie, N
Ginestier, C
Groulet, A
Charafe-Jauffret, E
Adélaïde, J
Geneix, J
Bachelart, L
Finetti, P
Koki, A
Hermitte, F
Hassoun, J
Debono, S
Viens, P
Fert, V
Jacquemier, J
Birnbaum, D
ONCOGENE, 2004, 23 (14) : 2564 - 2575
[16] miR-1296-5p decreases ERBB2 expression to inhibit the cell proliferation in ERBB2-positive breast cancer
Chen, Gang
He, Mingfeng
Yin, Yin
Yan, Ting
Cheng, Wenfang
Huang, Zebo
Zhang, Lan
Zhang, Huo
Liu, Ping
Zhu, Wei
Zhu, Yichao
CANCER CELL INTERNATIONAL, 2017, 17
[17] Photo-Activated Psoralen Binds the ErbB2 Catalytic Kinase Domain, Blocking ErbB2 Signaling and Triggering Tumor Cell Apoptosis
Xia, Wenle
Gooden, David
Liu, Leihua
Zhao, Sumin
Soderblom, Erik J.
Toone, Eric J.
Beyer, Wayne F., Jr.
Walder, Harold
Spector, Neil L.
PLOS ONE, 2014, 9 (02):
[18] Proliferation of Colorectal Cancer Is Promoted by Two Signaling Transduction Expression Patterns: ErbB2/ErbB3/AKT and MET/ErbB3/MAPK
Yao, Yong-Liang
Shao, Jie
Zhang, Chunfu
Wu, Jian-Hong
Zhang, Qing-Hui
Wang, Jian-Jun
Zhu, Wei
PLOS ONE, 2013, 8 (10):
[19] ERBB2 oncogene in human breast cancer and its clinical significance
Révillion, F
Bonneterre, J
Peyrat, JP
EUROPEAN JOURNAL OF CANCER, 1998, 34 (06) : 791 - 808
[20] ERBB2 juxtamembrane domain (trastuzumab binding site) gene mutation is a rare event in invasive breast cancers overexpressing the ERBB2 gene
Khoury, Thaer
Mojica, Wilfrido
Hicks, David
Starostik, Petr
Ademuyiwa, Foluso
Janarthanan, Bagirathan
Cheney, Richard T.
MODERN PATHOLOGY, 2011, 24 (08) : 1055 - 1059

← 1 2 3 4 5 →