Continuous Positive Airway Pressure Treatment for Obstructive Sleep Apnea Does Not Reduce Arterial Stiffness in Patients With Type 2 Diabetes After One Year of Follow-Up

被引：0

作者：

Krogager, Christoffer ^{[1
,2
,3
,4
]}

Banghoj, Anne Margareta ^{[5
]}

Poulsen, Per L. ^{[3
]}

Kirkegaard, Martin G. ^{[6
]}

Thorsteinsson, Birger ^{[5
,7
]}

Tarnow, Lise ^{[5
,8
]}

Laugesen, Esben ^{[3
]}

Hansen, Klavs W. ^{[2
]}

机构：

[1] Aarhus Univ, Dept Clin Med, Palle Juul Jensens Blvd 82, DK-8200 Aarhus, Denmark

[2] Reg Hosp Silkeborg, Diagnost Ctr, Falkevej 1A, DK-8600 Silkeborg, Denmark

[3] Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark

[4] Danish Diabet Acad, Sondre Blvd 29, DK-5000 Odense, Denmark

[5] Nordsjaellands Hosp, Dept Cardiol Nephrol & Endocrinol, Dyrehavevej 29, DK-3400 Hillerod, Denmark

[6] Reg Hosp Silkeborg, Elect Surg Ctr, Sleep Disorders Clin, Falkevej 1A, DK-8600 Silkeborg, Denmark

[7] Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark

[8] Steno Diabet Ctr Zealand, Birkevaenget 3,3 Sal, DK-4300 Holbaek, Denmark

来源：

JOURNAL OF ENDOCRINOLOGY AND METABOLISM | 2021年 / 11卷 / 05期

关键词：

Arterial stiffness; Pulse wave velocity; Diabetes; Obstructive sleep apnea; EXPERT CONSENSUS DOCUMENT; AORTIC STIFFNESS; WALL COMPLIANCE; MORTALITY; MELLITUS; PEOPLE; CPAP; LIFE;

D O I：

10.14740/jem773

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The aim of this study is to evaluate the effects of 12-month continuous positive airway pressure (CPAP) treatment on arterial stiffness in patients with type 2 diabetes. Methods: Obstructive sleep apnea (OSA) and type 2 diabetes frequently co-exists. Both diseases increase arterial stiffness, a marker of cardiovascular risk. Treating OSA with CPAP may lower arterial stiffness. In a recent randomized trial, we found that CPAP treatment for 12 weeks did not reduce arterial stiffness in type 2 diabetes patients with OSA. Participants from the randomized trial were invited to a follow-up study 12 months after inclusion. We evaluated arterial stiffness by measuring carotid-femoral pulse wave velocity (cfPWV) using SphygmoCor. Results: Forty-six patients (63.9% of the original 72 patients, age 63.8 +/- 6.5 years, diabetes duration 16.1 +/- 9.7 years, body mass index (BMI) 34.7 +/- 3.9 kg/m 2 ) partook in the study. Mean duration of CPAP treatment was 10.5 +/- 1.5 months. Baseline cfPWV was 10.7 in/s. At follow-up cfPWV was 10.6 m/s, change in cfPWV: -0.12 m/s, 95% confidence interval (CI): -0.6, 0.4, P = 0.6. Baseline systolic blood pressure (BP) was 136.2 mm Hg. At follow-up BP was 137.9 min Hg, change in BP: 1.6 nun Hg, 95% CI: -2.3, 5.5. Conclusions: We found no effect of 9 - 12-month CPAP treatment on arterial stiffness or BP in patients with long duration of type 2 diabetes and OSA.

引用

页码：134 / 139

页数：6

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