Contributions of microorganisms to industrial biology

被引：122

作者：

Demain, Arnold L. ^{[1
]}

Adrio, Jose L. ^{[2
]}

机构：

[1] Drew Univ, Res Inst Sci Emeriti, Madison, NJ 07940 USA

[2] NeuronBioPharma SA, BIC Granada, E-18100 Granada, Spain

来源：

MOLECULAR BIOTECHNOLOGY | 2008年 / 38卷 / 01期

关键词：

primary metabolites; secondary metabolites; bioconversions; enzymes; hosts; biopharmaceuticals; metabolic engineering; agriculture; polymers;

D O I：

10.1007/s12033-007-0035-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Life on earth is not possible without microorganisms. Microbes have contributed to industrial science for over 100 years. They have given us diversity in enzymatic content and metabolic pathways. The advent of recombinant DNA brought many changes to industrial microbiology. New expression systems have been developed, biosynthetic pathways have been modified by metabolic engineering to give new metabolites, and directed evolution has provided enzymes with modified selectability, improved catalytic activity and stability. More and more genomes of industrial microorganisms are being sequenced giving valuable information about the genetic and enzymatic makeup of these valuable forms of life. Major tools such as functional genomics, proteomics, and metabolomics are being exploited for the discovery of new valuable small molecules for medicine and enzymes for catalysis.

引用

页码：41 / 55

页数：15

共 124 条

[1] Enzymatic synthesis and modification of polymers in nonaqueous solvents [J].

Akkara, JA ;

Ayyagari, MSR ;

Bruno, FF .

TRENDS IN BIOTECHNOLOGY, 1999, 17 (02) :67-73

[2] MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT [J].

ALBERTS, AW ;

CHEN, J ;

KURON, G ;

HUNT, V ;

HUFF, J ;

HOFFMAN, C ;

ROTHROCK, J ;

LOPEZ, M ;

JOSHUA, H ;

HARRIS, E ;

PATCHETT, A ;

MONAGHAN, R ;

CURRIE, S ;

STAPLEY, E ;

ALBERSSCHONBERG, G ;

HENSENS, O ;

HIRSHFIELD, J ;

HOOGSTEEN, K ;

LIESCH, J ;

SPRINGER, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07) :3957-3961

[3]

*AM AC MICR COLL, 2004, MICR 21 CENT WE AR W

[4] Direct fermentative production of acyltylosins by genetically-engineered strains of Streptomyces fradiae [J].

Arisawa, A ;

Kawamura, N ;

Narita, T ;

Kojima, I ;

Okamura, K ;

Tsunekawa, H ;

Yoshioka, T ;

Okamoto, R .

JOURNAL OF ANTIBIOTICS, 1996, 49 (04) :349-354

[5] Combinatorial and computational challenges for biocatalyst design [J].

Arnold, FH .

NATURE, 2001, 409 (6817) :253-257

[6] MODIFICATION OF MILK-CLOTTING ASPARTIC PROTEINASES BY RECOMBINANT-DNA TECHNIQUES [J].

BEPPU, T .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1990, 613 :14-25

[7]

BIGELIS R, 1989, BIOTECHNOLOGY B, V7, P229

[8] STRAIN IMPROVEMENT OF CHYMOSIN-PRODUCING STRAINS OF ASPERGILLUS-NIGER VAR AWAMORI USING PARASEXUAL RECOMBINATION [J].

BODIE, EA ;

ARMSTRONG, GL ;

DUNNCOLEMAN, NS .

ENZYME AND MICROBIAL TECHNOLOGY, 1994, 16 (05) :376-382

[9] De novo design of biocatalysts [J].

Bolon, DN ;

Voigt, CA ;

Mayo, SL .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (02) :125-129

[10] Metabolic engineering for microbial production of aromatic amino acids and derived compounds [J].

Bongaerts, J ;

Krämer, M ;

Müller, U ;

Raeven, L ;

Wubbolts, M .

METABOLIC ENGINEERING, 2001, 3 (04) :289-300

← 1 2 3 4 5 6 7 8 9 10 →