Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process?

被引：82
作者：
Jullien, Jerome
Pasque, Vincent
Halley-Stott, Richard P.
Miyamoto, Kei
Gurdon, J. B. [1 ]
机构：
[1] Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 07期
基金：
新加坡国家研究基金会; 英国惠康基金; 日本学术振兴会;
关键词：
LINKER HISTONE; GENE-EXPRESSION; SOMATIC NUCLEI; DNA DEMETHYLATION; CHROMATIN; PLURIPOTENCY; TRANSCRIPTION; CELLS; METHYLATION; OCT4;
D O I：
10.1038/nrm3140
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Differentiated cells can be experimentally reprogrammed back to pluripotency by nuclear transfer, cell fusion or induced pluripotent stem cell technology. Nuclear transfer and cell fusion can lead to efficient reprogramming of gene expression. The egg and oocyte reprogramming process includes the exchange of somatic proteins for oocyte proteins, the post-translational modification of histones and the demethylation of DNA. These events occur in an ordered manner and on a defined timescale, indicating that reprogramming by nuclear transfer and by cell fusion rely on deterministic processes.
引用
收藏
页码：453 / 459
页数：7
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