Staphylococcus aureus positive for Panton-Valentine leukocidin genes but susceptible to methicillin in patients with furuncles

被引:13
作者
Nolte, O
Haag, H
Zimmerman, A
Geiss, HK
机构
[1] Inst Hyg, Dept Hyg & Med Microbiol, D-69120 Heidelberg, Germany
[2] Inst Hyg, Dept Virol, D-69120 Heidelberg, Germany
关键词
D O I
10.1007/s10096-005-1354-2
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
A total of 75 Staphylococcus aureus isolates obtained from patients with either recurrent skin abscesses or furuncles (n=48) or chronic infections from other body sites (n=27) were screened for the presence of the lukS-PV and lukF-PV genes encoding Panton-Valentine leukocidin. Significantly more isolates (70.8% vs. 7.4%, p < 0.001) from patients suffering skin abscesses or furuncles were positive for lukS-PV and lukF-PV. These isolates belonged to the accessory gene regulator (agr) group Ia (9/48), group III (13/48), or group IV (19/48). In contrast with results of other investigations, none of the isolates positive for the Panton-Valentine leukocidin genes in this study exhibited methicillin resistance.
引用
收藏
页码:477 / 479
页数:3
相关论文
共 12 条
  • [1] Toxin genes and other characteristics of Staphylococcus aureus isolates from milk of cows with mastitis
    Akineden, Ö
    Annemüller, C
    Hassan, AA
    Lämmler, C
    Wolter, W
    Zschöck, M
    [J]. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2001, 8 (05) : 959 - 964
  • [2] Community-onset methicillin-resistant Staphylococcus aureus associated with antibiotic use and the cytotoxin Panton-Valentine leukocidin during a furunculosis outbreak in rural Alaska
    Baggett, HC
    Hennessy, TW
    Rudolph, K
    Bruden, D
    Reasonover, A
    Parkinson, A
    Sparks, R
    Donlan, RM
    Martinez, P
    Mongkolrattanothai, K
    Butler, JC
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2004, 189 (09) : 1565 - 1573
  • [3] Rapid and specific detection of toxigenic Staphylococcus aureus:: Use of two multiplex PCR enzyme immunoassays for amplification and hybridization of staphylococcal enterotoxin genes, exfoliative toxin genes, and toxic shock syndrome toxin 1 gene
    Becker, K
    Roth, R
    Peters, G
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (09) : 2548 - 2553
  • [4] Panton-Valentine leukocidin and staphyloccoccal skin infections in schoolchildren
    Boubaker, K
    Diebold, P
    Blanc, DS
    Vandenesch, F
    Praz, G
    Dupuis, G
    Troillet, N
    [J]. EMERGING INFECTIOUS DISEASES, 2004, 10 (01) : 121 - 124
  • [5] *EURO ATVO CARD CO, 2002, AUT THER VACC COMB A
  • [6] Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus
    Jarraud, S
    Lyon, GJ
    Figueiredo, AMS
    Gérard, L
    Vandenesch, F
    Etienne, J
    Muir, TW
    Novick, RP
    [J]. JOURNAL OF BACTERIOLOGY, 2000, 182 (22) : 6517 - 6522
  • [7] Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia
    Lina, G
    Piémont, Y
    Godail-Gamot, F
    Bes, M
    Peter, MO
    Gauduchon, V
    Vandenesch, F
    Etienne, J
    [J]. CLINICAL INFECTIOUS DISEASES, 1999, 29 (05) : 1128 - 1132
  • [8] Species-specific and ubiquitous-DNA-based assays for rapid identification of Staphylococcus aureus
    Martineau, F
    Picard, FJ
    Roy, PH
    Ouellete, M
    Bergeron, MG
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (03) : 618 - 623
  • [9] Molecular analysis of the accessory gene regulator (agr) locus and balance of virulence factor expression in epidemic methicillin-resistant Staphylococcus aureus
    Papakyriacou, H
    Vaz, D
    Simor, A
    Louie, M
    McGavin, MJ
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (03) : 990 - 1000
  • [10] Projan S.J., 1997, The Staphylococci in human diseases, P55