Wernicke Encephalopathy Presenting with Dysphagia: A Case Report and Systematic Literature Review

被引:5
|
作者
Cornea, Amalia [1 ,2 ]
Lata, Irina [2 ]
Simu, Mihaela [1 ,2 ]
Rosca, Elena Cecilia [1 ,2 ]
机构
[1] Victor Babes Univ Med & Pharm Timisoara, Dept Neurol, Eftimie Murgu Sq 2, Timisoara 300041, Romania
[2] Clin Emergency Cty Hosp Timisoara, Dept Neurol, Bd Losif Bulbuca 10, Timisoara 300736, Romania
关键词
wernicke encephalopathy; thiamine; dysphagia; DIAGNOSIS; SERIES; RARE;
D O I
10.3390/nu14245294
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Wernicke encephalopathy (WE) is a well-known neurological condition caused by thiamine (vitamin B1) deficiency that occurs in both alcoholic and non-alcoholic populations. We aimed to report a case of a patient with WE who presented with dysphagia and dysphonia and later developed typical symptoms of thiamine deficiency and to conduct a systematic review of the literature on this rare presentation of WE. We searched two databases (PubMed and Scopus) and included publications up to November 2022. We found 12 cases of WE and dysphagia, aged between 12 and 81 years; swallowing problems presented at the onset in nine patients (including the current case report). Our findings suggest that thiamine deficiency should be suspected in patients with dysphagia of unknown cause, even in the absence of alcohol abuse. In contrast to most WE patients, the majority of patients included in this review presented with dysphagia at the onset of their disease, even in the absence of the classic triad of cognitive impairment, ataxia, and oculomotor abnormalities, indicating that there could be varying susceptibilities to clinical manifestations of thiamine deficiency in different brain regions.
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页数:13
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