A comparative synthesis of 6-benzyl-2,3-dihydroimidazo[2,1-a]phthalazine and 2H-7-benzyl-3,4-dihydropyrimido[2,1-a]phthalazine

被引：9

作者：

Munin, Javier ^{[1
,2
]}

Santana, Lourdes ^{[2
]}

Uriarte, Eugenio ^{[2
]}

Borges, Fernanda ^{[3
]}

Quezada, Elias ^{[3
]}

机构：

[1] Univ Santiago de Compostela, Fac Farm, Dept Farmacol, Santiago De Compostela 15782, Spain

[2] Univ Santiago de Compostela, Fac Farm, Dept Quim Organ, Santiago De Compostela 15782, Spain

[3] Univ Porto, Fac Ciencias, Dept Quim & Bioquim, P-4169007 Oporto, Portugal

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 06期

关键词：

Synthesis; Imidazophthalazine; Pyrimidophthalazine; Cyclization; Condensation; AMINOPHTHALAZINONE DERIVATIVES; RING-SYSTEMS;

D O I：

10.1016/j.tetlet.2014.12.121

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new synthetic strategies have been developed for the synthesis of a new class of cyclophthalazine derivatives. 6-BenzyL-2,3-dihydroimidazo[2,1-a]phthalazine and 2H-7-benzyl-3,4-dihydropyrimido[2,1-a]phthalazine were obtained (i) by intramolecular cyclization of the 2-(aminoalkyl)-4-benzyl-2H-phthalazin-1-one or (ii) by intramolecular cyclization of the corresponding 2-(4-benzylphthalazin-1(2H)-ylide-neamino)alcohols previously prepared. The second of the described routes afforded the desired derivatives in high yields. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：828 / 830

页数：3

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