Fabrication, multi-scale characterization and in-vitro evaluation of porous hybrid bioactive glass polymer-coated scaffolds for bone tissue engineering

被引：23

作者：

Chlanda, Adrian ^{[1
]}

Oberbek, Przemyslaw ^{[1
,2
]}

Heljak, Marcin ^{[1
]}

Kijenska-Gawronska, Ewa ^{[1
]}

Bolek, Tomasz ^{[1
]}

Gloc, Michal ^{[1
]}

John, Lukasz ^{[3
]}

Janeta, Mateusz ^{[3
]}

Wozniak, Michal J. ^{[1
,4
]}

机构：

[1] Warsaw Univ Technol, Fac Mat Sci & Engn, Woloska 141, PL-02507 Warsaw, Poland

[2] Natl Res Inst, Cent Inst Labour Protect, Czemiakowska 16, PL-00701 Warsaw, Poland

[3] Univ Wroclaw, Fac Chem, F Joliot Curie 14, PL-50383 Wroclaw, Poland

[4] MJW RnD, Nowy Swiat 33-13, PL-00029 Warsaw, Poland

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2019年 / 94卷

关键词：

Tissue engineering; Scaffold; Bioactive glass; Mechanical properties; SHAPE-MEMORY ALLOY; CERAMIC SCAFFOLDS; REGENERATIVE MEDICINE; FOAM SCAFFOLDS; CELL-ADHESION; SOFT-TISSUE; SURFACE; COMPOSITES; STIFFNESS; OPTIMIZATION;

D O I：

10.1016/j.msec.2018.09.062

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Bioactive glass-based scaffolds are commonly used in bone tissue engineering due to their biocompatibility, mechanical strength and adequate porous structure. However, their hydrophobicity and brittleness limits their practical application. In this study, to improve nanomechanical properties of such scaffolds, pure bioactive hybrid glass and two bioactive hybrid glass-polymer coated composites were fabricated. A complementary micro and nanoscale characterization techniques (SEM, AFM, mu CT, FTIR, compressive test, goniometer) were implemented for detailed description of architecture and physicochemical properties of hybrid bioactive glass-based scaffolds with emphasis on nano-mechanics. The final step was in-vitro evaluation of three dimensional macroporous structures. Our findings show that after polymer addition, architecture, topography and surface properties of the scaffolds were changed and promoted favoured behaviour of the cells.

引用

页码：516 / 523

页数：8

共 84 条

[1] Bi-layered porous constructs of PCL-coated 45S5 bioactive glass and electrospun collagen-PCL fibers [J].