Neovascularization and Synaptic Function Regulation with Memantine and Rosuvastatin in a Rat Model of Chronic Cerebral Hypoperfusion

被引：14

作者：

Zhang, Nan ^{[1
,2
]}

Song, Chenchen ^{[1
,3
]}

Zhao, Baomin ^{[1
,4
]}

Xing, Mengya ^{[1
]}

Luo, Lanlan ^{[1
]}

Gordon, Marc L. ^{[2
]}

Cheng, Yan ^{[1
]}

机构：

[1] Tianjin Med Univ, Tianjin Neurol Inst, Dept Neurol, Gen Hosp, 154 Anshan Rd, Tianjin 300052, Peoples R China

[2] Feinstein Inst Med Res, Litwin Zucker Res Ctr, 350 Community Dr, Manhasset, NY 11030 USA

[3] 254 Hosp PLA, Dept Neurol, Tianjin, Peoples R China

[4] Yidu Cent Hosp Weifang, Dept Neurol, Qingzhou, Peoples R China

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2017年 / 63卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Chronic cerebral hypoperfusion; Endothelial progenitor cell; Long-termpotentiation; Memantine; Rosuvastatin; ENDOTHELIAL PROGENITOR CELLS; VASCULAR DEMENTIA; ALZHEIMERS-DISEASE; NEONATAL-RATS; BRAIN-INJURY; UDP-GLUCOSE; BDNF; ISCHEMIA; MEMORY; MICE;

D O I：

10.1007/s12031-017-0974-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cerebral hypoperfusion is an important factor in the pathogenesis of cerebrovascular diseases and neurodegenerative disorders. We investigated the effects of memantine and rosuvastatin on both neovascularization and synaptic function in a rat model of chronic cerebral hypoperfusion, which was established by the bilateral common carotid occlusion (2VO) method. We tested learning and memory ability, synaptic function, circulating endothelial progenitor cell (EPC) number, expression of neurotrophic factors, and markers of neovasculogenesis and cell proliferation after memantine and/or rosuvastatin treatment. Rats treated with memantine and/or rosuvastatin showed significant improvement in Morris water maze task and long-term potentiation (LTP) in the hippocampus, compared with untreated 2VO model rats. Circulating EPCs, expression of brain-derived neurotrophic factor, and vascular endothelial growth factor, markers of microvessel density were increased by each of the three interventions. Rosuvastatin also increased cell proliferation in the hippocampus. Combined treatment with memantine and rosuvastatin showed greater effect on enhancement of LTP and expression of neurotrophic factors than either single medication treatment alone. Both memantine and rosuvastatin improved learning and memory, enhanced neovascularization and synaptic function, and upregulated neurotrophic factors in a rat model of chronic cerebral hypoperfusion.

引用

页码：223 / 232

页数：10

共 51 条

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