Metalloproteinases in Rheumatoid Arthritis: Potential Therapeutic Targets to Improve Current Therapies

被引:66
作者
Itoh, Yoshifumi [1 ]
机构
[1] Univ Oxford, Kennedy Inst Rheumatol, Oxford, England
来源
MATRIX METALLOPROTEINASES AND TISSUE REMODELING IN HEALTH AND DISEASE: TARGET TISSUES AND THERAPY | 2017年 / 148卷
基金
英国医学研究理事会;
关键词
TUMOR-NECROSIS-FACTOR; TYPE-1; MATRIX-METALLOPROTEINASE; THROMBOTIC THROMBOCYTOPENIC PURPURA; COLLAGEN-INDUCED ARTHRITIS; HARD TISSUE JUNCTION; INFLAMMATORY ARTHRITIS; 1-MATRIX METALLOPROTEINASE; CARTILAGE DESTRUCTION; SELECTIVE-INHIBITION; MONOCLONAL-ANTIBODY;
D O I
10.1016/bs.pmbts.2017.03.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by the destruction of joint tissues including cartilage and bone. Cartilage degradation is attributed to metalloproteinases (MPs) that belong to matrix metalloproteinase family and a disintegrin and metalloprotease with thrombospondin type 1 motifs produced by inflamed joint tissues. In addition, an enzyme that belongs to a disintegrin and metalloprotease family is also involved in release of inflammatory cytokines. Several highly selective inhibitors have been developed for MPs thought to play a role in RA pathogenesis and examining these inhibitors as potential drugs is becoming realistic. This chapter discusses recent reports on MPs in RA and their potential as a therapeutic target.
引用
收藏
页码:327 / 338
页数:12
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