Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs

被引：29

作者：

El Brahmi, Nabil ^{[1
,2
]}

Mignani, Serge M. ^{[3
]}

Caron, Joachim ^{[1
,2
]}

El Kazzouli, Said ^{[2
]}

Bousmina, Mosto M. ^{[2
]}

Caminade, Anne-Marie ^{[1
]}

Cresteil, Thierry ^{[4
]}

Majoral, Jean-Pierre ^{[1
]}

机构：

[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse 4, France

[2] Euromediterranean Univ Fes, Div Engn, Euromed Res Inst, Fes 30070, Morocco

[3] Univ Paris 05, PRES Sorbonne Paris Cite, CNRS UMR 860, Lab Chim & Biochim Pharmacol & Toxicol, F-75006 Paris, France

[4] Univ Paris 11, IFR141, IPSIT, F-92290 Chatenay Malabry, France

来源：

NANOSCALE | 2015年 / 7卷 / 09期

关键词：

S-TRANSFERASE P1-1; PI-CLASS GLUTATHIONE; IN-VIVO EFFICACY; LEUKEMIA-CELLS; DERIVATIVES; APOPTOSIS; ANALOGS; NANOMEDICINE; COMPLEXES; TOXICITY;

D O I：

10.1039/c4nr05983b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The well-known reactive diuretic ethacrynic acid (EA, Edecrin), with low antiproliferative activities, was chemically modified and grafted onto phosphorus dendrimers and the corresponding simple branched phosphorus dendron-like derivatives affording novel nanodevices showing moderate to strong antiproliferative activities against liquid and solid tumor cell lines, respectively.

引用

页码：3915 / 3922

页数：8

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