Spoligotypes of Mycobacterium tuberculosis from Different Provinces of China

被引：69

作者：

Dong, Haiyan ^{[1
]}

Liu, Zhiguang ^{[1
]}

Lv, Bing ^{[1
]}

Zhang, Yuanyuan ^{[1
]}

Liu, Jie ^{[1
]}

Zhao, Xiuqin ^{[1
]}

Liu, Jinghua ^{[1
]}

Wan, Kanglin ^{[1
]}

机构：

[1] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2010年 / 48卷 / 11期

关键词：

STRAIN DIFFERENTIATION; COMPLEX; GENOTYPE; POLYMORPHISM; DATABASE; REGION; IS6110; DELHI;

D O I：

10.1128/JCM.00549-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A total of 2,346 Mycobacterium tuberculosis isolates from 13 provinces in China were genotyped by spoligotyping. Two hundred seventy-eight spoligotypes were identified: 2,153 isolates were grouped into 85 clusters, and the remaining 193 isolates were orphans. Comparison with the SpolDB4.0 database revealed that 118 spoligotypes had shared international type numbers in the database and the other 160 were novel. These 160 novel spoligotypes were assigned to families and subfamilies using the SpotClust program. The most prevalent family was the Beijing family (74.08%), followed by the T family (14.11%). CAS family strains were found only in the Xinjiang and Tibet regions, while EAI family strains were found only in Fujian Province. In conclusion, the present study of the M. tuberculosis population in China demonstrated that Beijing family isolates are the most prevalent strains in China and that they exhibit geographical variation. Furthermore, many new spoligotypes were found in this study.

引用

页码：4102 / 4106

页数：5

共 25 条

[1] Ancestral Mycobacterium tuberculosis genotypes in India: Implications for TB control programmes [J].

Ahmed, Niyaz ;

Ehtesham, Nasreen Z. ;

Hasnain, Seyed E. .

INFECTION GENETICS AND EVOLUTION, 2009, 9 (01) :142-146

[2] Predominace of a novel Mycobacterium tuberculosis genotype in the Delhi region of India [J].

Bhanu, NV ;

van Soolingen, D ;

van Embden, JDA ;

Dar, L ;

Pandey, RM ;

Seth, P .

TUBERCULOSIS, 2002, 82 (2-3) :105-112

[3] Global dissemination of the Mycobacterium tuberculosis W-Beijing family strains [J].

Bifani, PJ ;

Mathema, B ;

Kurepina, NE ;

Kreiswirth, BN .

TRENDS IN MICROBIOLOGY, 2002, 10 (01) :45-52

[4] A new evolutionary scenario for the Mycobacterium tuberculosis complex [J].

Brosch, R ;

Gordon, SV ;

Marmiesse, M ;

Brodin, P ;

Buchrieser, C ;

Eiglmeier, K ;

Garnier, T ;

Gutierrez, C ;

Hewinson, G ;

Kremer, K ;

Parsons, LM ;

Pym, AS ;

Samper, S ;

van Soolingen, D ;

Cole, ST .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3684-3689

[5] Mycobacterium tuberculosis complex genetic diversity:: mining the fourth international spoligotyping database (SpoIDB4) for classification, population genetics and epidemiology [J].

Brudey, Karine ;

Driscoll, Jeffrey R. ;

Rigouts, Leen ;

Prodinger, Wolfgang M. ;

Gori, Andrea ;

Al-Hajoj, Sahal A. ;

Allix, Caroline ;

Aristimuno, Liselotte ;

Arora, Jyoti ;

Baumanis, Viesturs ;

Binder, Lothar ;

Cafrune, Patricia ;

Cataldi, Angel ;

Cheong, Soonfatt ;

Diel, Roland ;

Ellermeier, Christopher ;

Evans, Jason T. ;

Fauville-Dufaux, Maryse ;

Ferdinand, Severine ;

Garcia de Viedma, Dario ;

Garzelli, Carlo ;

Gazzola, Lidia ;

Gomes, Harrison M. ;

Guttierez, M. Cristina ;

Hawkey, Peter M. ;

van Helden, Paul D. ;

Kadival, Gurujaj V. ;

Kreiswirth, Barry N. ;

Kremer, Kristin ;

Kubin, Milan ;

Kulkarni, Savita P. ;

Liens, Benjamin ;

Lillebaek, Troels ;

Ly, Ho Minh ;

Martin, Carlos ;

Martin, Christian ;

Mokrousov, Igor ;

Narvskaia, Olga ;

Ngeow, Yun Fong ;

Naumann, Ludmilla ;

Niemann, Stefan ;

Parwati, Ida ;

Rahim, Zeaur ;

Rasolofo-Razanamparany, Voahangy ;

Rasolonavalona, Tiana ;

Rossetti, M. Lucia ;

Ruesch-Gerdes, Sabine ;

Sajduda, Anna ;

Samper, Sofia ;

Shemyakin, Igor G. .

BMC MICROBIOLOGY, 2006, 6 (1)

[6] IS6110 - CONSERVATION OF SEQUENCE IN THE MYCOBACTERIUM-TUBERCULOSIS COMPLEX AND ITS UTILIZATION IN DNA FINGERPRINTING [J].

CAVE, MD ;

EISENACH, KD ;

MCDERMOTT, PF ;

BATES, JH ;

CRAWFORD, JT .

MOLECULAR AND CELLULAR PROBES, 1991, 5 (01) :73-80

[7] Evolutionary relationships among strains of Mycobacterium tuberculosis with few copies of IS6110 [J].

Dale, JW ;

Al-Ghusein, H ;

Al-Hashmi, S ;

Butcher, P ;

Dickens, AL ;

Drobniewski, F ;

Forbes, KJ ;

Gillespie, SH ;

Lamprecht, D ;

McHugh, TD ;

Pitman, R ;

Rastogi, N ;

Smith, AT ;

Sola, C ;

Yesilkaya, H .

JOURNAL OF BACTERIOLOGY, 2003, 185 (08) :2555-2562

[8]

Duanmu Hongjin, 2002, Zhonghua Jiehe He Huxi Zazhi, V25, P3

[9]

Glynn JR, 2002, EMERG INFECT DIS, V8, P843

[10] NATURE OF DNA POLYMORPHISM IN THE DIRECT REPEAT CLUSTER OF MYCOBACTERIUM-TUBERCULOSIS - APPLICATION FOR STRAIN DIFFERENTIATION BY A NOVEL TYPING METHOD [J].

GROENEN, PMA ;

BUNSCHOTEN, AE ;

VANSOOLINGEN, D ;

VANEMBDEN, JDA .

MOLECULAR MICROBIOLOGY, 1993, 10 (05) :1057-1065

← 1 2 3 →