Vedolizumab therapy for pediatric steroid-refractory gastrointestinal acute graft-versus-host disease

被引：6

作者：

Isshiki, Kyohei ^{[1
]}

Kamiya, Takahiro ^{[2
]}

Endo, Akifumi ^{[2
]}

Okamoto, Kentaro ^{[3
]}

Osumi, Tomoo ^{[1
]}

Kawai, Toshinao ^{[4
]}

Arai, Katsuhiro ^{[5
]}

Tomizawa, Daisuke ^{[1
]}

Ohtsuka, Kazuo ^{[6
]}

Nagahori, Masakazu ^{[6
]}

Imai, Kohsuke ^{[2
]}

Kato, Motohiro ^{[1
]}

Kanegane, Hirokazu ^{[2
]}

机构：

[1] Natl Ctr Child Hlth & Dev, Childrens Canc Ctr, Setagaya Ku, 2-10-1 Okura, Tokyo 1578535, Japan

[2] Tokyo Med & Dent Univ Hosp, Dept Pediat, Tokyo, Japan

[3] Tokyo Med & Dent Univ Hosp, Dept Pediat Surg, Tokyo, Japan

[4] Natl Ctr Child Hlth & Dev, Div Immunol, Tokyo, Japan

[5] Natl Ctr Child Hlth & Dev, Div Gastroenterol, Tokyo, Japan

[6] Tokyo Med & Dent Univ Hosp, Dept Gastroenterol & Hepatol, Tokyo, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2022年 / 115卷 / 04期

关键词：

Vedolizumab; GVHD; Children; Gastrointestinal tract; Refractory; MAINTENANCE THERAPY; INDUCTION;

D O I：

10.1007/s12185-021-03245-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vedolizumab, an immunosuppressive drug that acts locally on the gastrointestinal tract, is mainly used for the treatment of inflammatory bowel disease, and has been reported to be effective against gastrointestinal acute graft-versus-host disease (GI-aGVHD) in adults. However, there is insufficient evidence for pediatric GI-aGVHD. We used vedolizumab to treat three cases of GI-aGVHD in patients aged 1.5-4.4 years. It was significantly effective in two patients and did not cause serious side effects in any patient. Vedolizumab might be effective and safe for pediatric GI-aGVHD refractory to other treatments, but this must be confirmed in future studies.

引用

页码：590 / 594

页数：5

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