Evidence for cell proliferation in the sheep brain and its down-regulation by parturition and interactions with the young

被引:52
作者
Brus, M.
Meurisse, M.
Franceschini, I.
Keller, M.
Levy, F. [1 ]
机构
[1] INRA, Physiol Reprod & Comportements UMR 85, F-37380 Nouzilly, France
关键词
Neurogenesis; Maternal behavior; Olfaction; Neuronal progenitor; Subventricular zone; Hippocampus; Main olfactory bulb; Ewe; Social behavior; Dentate gyrus; NEURAL STEM-CELLS; ADULT MAMMALIAN BRAIN; SUBVENTRICULAR ZONE ASTROCYTES; NEWLY-GENERATED NEURONS; CENTRAL-NERVOUS-SYSTEM; OLFACTORY-BULB; DENTATE GYRUS; MATERNAL-BEHAVIOR; HIPPOCAMPAL NEUROGENESIS; MESSENGER-RNA;
D O I
10.1016/j.yhbeh.2010.07.006
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Production of new neurons continues throughout life in the subventricular zone (SVZ) and the dentate gyrus (DG) of the hippocampus and is influenced by both endocrine and social factors. In sheep parturition is associated with the establishment of a selective bond with the young based on an olfactory learning. The possibility exists that endocrine changes at parturition together with interactions with the young modulate cell proliferation in the neurogenic zones. In the present study, we first investigated the existence of cell proliferation in sheep. Newly born cells labeled by the cell proliferation marker 5-bromo-2'-deoxyuridine (BrdU) were found in the SVZ, the main olfactory bulb (MOB) and the DG and completely co-localized with Ki-67, another mitotic marker. Forty to 50% of the BrdU-labeled cells contained GFAP suggestive of the presence of neural stem cells. Secondly, parturition with or without interactions with the lamb for 2 days, down-regulated the number of BrdU-labeled cells in the 3 proliferation sites in comparison to no pregnancy. An additional control provided evidence that this effect is specific to early postpartum period: estrus with interactions with males did not affect cell proliferation. Our results provide the first characterization of neural cell proliferation in the SVZ, the DG and unexpectedly in the MOB of adult sheep. We hypothesize that the down-regulation of cell proliferation observed in the early postpartum period could facilitate the olfactory perceptual and memory demands associated with maternal behavior by favouring the survival and integration of neurons born earlier. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:737 / 746
页数:10
相关论文
共 71 条
[1]   Adult neurogenesis: From precursors to network and physiology [J].
Abrous, DN ;
Koehl, M ;
Le Moal, M .
PHYSIOLOGICAL REVIEWS, 2005, 85 (02) :523-569
[2]   ARE NEW NEURONS FORMED IN BRAINS OF ADULT MAMMALS [J].
ALTMAN, J .
SCIENCE, 1962, 135 (3509) :1127-&
[3]   Identification of neural stem cells in the adult vertebrate brain [J].
Alvarez-Buylla, A ;
Seri, B ;
Doetsch, F .
BRAIN RESEARCH BULLETIN, 2002, 57 (06) :751-758
[4]   Neurogenesis in adult subventricular zone [J].
Alvarez-Buylla, A ;
García-Verdugo, JM .
JOURNAL OF NEUROSCIENCE, 2002, 22 (03) :629-634
[5]   Serotonin mediates oestrogen stimulation of cell proliferation in the adult dentate gyrus [J].
Banasr, M ;
Hery, M ;
Brezun, JM ;
Daszuta, A .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 14 (09) :1417-1424
[6]   Evidence of newly generated neurons in the human olfactory bulb [J].
Bédard, A ;
Parent, A .
DEVELOPMENTAL BRAIN RESEARCH, 2004, 151 (1-2) :159-168
[7]   Transient expression of doublecortin during adult neurogenesis [J].
Brown, JP ;
Couillard-Després, S ;
Cooper-Kuhn, CM ;
Winkler, J ;
Aigner, L ;
Kuhn, HG .
JOURNAL OF COMPARATIVE NEUROLOGY, 2003, 467 (01) :1-10
[8]   A theoretical network model to analyse neurogenesis and synaptogenesis in the dentate gyrus [J].
Butz, Markus ;
Lehmann, Konrad ;
Dammasch, Ingolf E. ;
Teuchert-Noodt, Gertraud .
NEURAL NETWORKS, 2006, 19 (10) :1490-1505
[9]   CHANGES IN LEVELS OF PROGESTERONE, CORTICOSTEROIDS, ESTRONE, ESTRADIOL-17 BETA, LUTEINIZING-HORMONE, AND PROLACTIN IN PERIPHERAL PLASMA OF EWE DURING LATE PREGNANCY AND AT PARTURITION [J].
CHAMLEY, WA ;
BUCKMASTER, JM ;
CERINI, ME ;
CUMMING, IA ;
GODING, JR ;
OBST, JM ;
WILLIAMS, A ;
WINFIELD, C .
BIOLOGY OF REPRODUCTION, 1973, 9 (01) :30-35
[10]   Early sexual experience and stressful conditions affect the response of young ewes to the male [J].
Chanvallon, A. ;
Scaramuzzi, R. J. ;
Fabre-Nys, C. .
PHYSIOLOGY & BEHAVIOR, 2010, 99 (04) :457-465