A Novel Regulatory Player in the Innate Immune System: Long Non-Coding RNAs

被引:13
|
作者
Xie, Yuhuai [1 ]
Wei, Yuanyuan [1 ,2 ]
机构
[1] Fudan Univ, Sch Basic Med Sci, Dept Immunol, Shanghai 200032, Peoples R China
[2] Fudan Univ, Sch Basic Med Sci, State Key Lab Med Neurobiol, Shanghai Key Lab Bioact Small Mol, Shanghai 200032, Peoples R China
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
long non-coding RNA; transcriptional regulation; inflammation; innate immunity; innate immune cells; NF-KAPPA-B; GENOME-WIDE ANALYSIS; GENE-EXPRESSION; CHROMATIN INTERACTIONS; INFLAMMATORY RESPONSE; MACROPHAGE ACTIVATION; MOLECULAR-MECHANISMS; PATTERN-RECOGNITION; MALAT1; CONTRIBUTES; STRANDED-RNA;
D O I
10.3390/ijms22179535
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Long non-coding RNAs (lncRNAs) represent crucial transcriptional and post-transcriptional gene regulators during antimicrobial responses in the host innate immune system. Studies have shown that lncRNAs are expressed in a highly tissue- and cell-specific-manner and are involved in the differentiation and function of innate immune cells, as well as inflammatory and antiviral processes, through versatile molecular mechanisms. These lncRNAs function via the interactions with DNA, RNA, or protein in either cis or trans pattern, relying on their specific sequences or their transcriptions and processing. The dysregulation of lncRNA function is associated with various human non-infectious diseases, such as inflammatory bowel disease, cardiovascular diseases, and diabetes mellitus. Here, we provide an overview of the regulation and mechanisms of lncRNA function in the development and differentiation of innate immune cells, and during the activation or repression of innate immune responses. These elucidations might be beneficial for the development of therapeutic strategies targeting inflammatory and innate immune-mediated diseases.
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页数:26
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