A Novel Regulatory Player in the Innate Immune System: Long Non-Coding RNAs
被引:13
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作者:
Xie, Yuhuai
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机构:
Fudan Univ, Sch Basic Med Sci, Dept Immunol, Shanghai 200032, Peoples R ChinaFudan Univ, Sch Basic Med Sci, Dept Immunol, Shanghai 200032, Peoples R China
Xie, Yuhuai
[1
]
Wei, Yuanyuan
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机构:
Fudan Univ, Sch Basic Med Sci, Dept Immunol, Shanghai 200032, Peoples R China
Fudan Univ, Sch Basic Med Sci, State Key Lab Med Neurobiol, Shanghai Key Lab Bioact Small Mol, Shanghai 200032, Peoples R ChinaFudan Univ, Sch Basic Med Sci, Dept Immunol, Shanghai 200032, Peoples R China
Wei, Yuanyuan
[1
,2
]
机构:
[1] Fudan Univ, Sch Basic Med Sci, Dept Immunol, Shanghai 200032, Peoples R China
[2] Fudan Univ, Sch Basic Med Sci, State Key Lab Med Neurobiol, Shanghai Key Lab Bioact Small Mol, Shanghai 200032, Peoples R China
Long non-coding RNAs (lncRNAs) represent crucial transcriptional and post-transcriptional gene regulators during antimicrobial responses in the host innate immune system. Studies have shown that lncRNAs are expressed in a highly tissue- and cell-specific-manner and are involved in the differentiation and function of innate immune cells, as well as inflammatory and antiviral processes, through versatile molecular mechanisms. These lncRNAs function via the interactions with DNA, RNA, or protein in either cis or trans pattern, relying on their specific sequences or their transcriptions and processing. The dysregulation of lncRNA function is associated with various human non-infectious diseases, such as inflammatory bowel disease, cardiovascular diseases, and diabetes mellitus. Here, we provide an overview of the regulation and mechanisms of lncRNA function in the development and differentiation of innate immune cells, and during the activation or repression of innate immune responses. These elucidations might be beneficial for the development of therapeutic strategies targeting inflammatory and innate immune-mediated diseases.
机构:
China Pharmaceut Univ, Dept Engn Res Ctr Peptide Drug Discovery & Dev, Nanjing 210009, Jiangsu, Peoples R China
China Pharmaceut Univ, Dept State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R ChinaChina Pharmaceut Univ, Dept Engn Res Ctr Peptide Drug Discovery & Dev, Nanjing 210009, Jiangsu, Peoples R China
Lin, Chen-Yu
Xu, Han-Mei
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China Pharmaceut Univ, Dept Engn Res Ctr Peptide Drug Discovery & Dev, Nanjing 210009, Jiangsu, Peoples R China
China Pharmaceut Univ, Dept State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R ChinaChina Pharmaceut Univ, Dept Engn Res Ctr Peptide Drug Discovery & Dev, Nanjing 210009, Jiangsu, Peoples R China
机构:
Univ Autonoma San Luis Potosi, Coordinac Acad Reg Altiplano, San Luis Potosi 78760, MexicoUniv Autonoma San Luis Potosi, Coordinac Acad Reg Altiplano, San Luis Potosi 78760, Mexico
Silva-Cazares, Macrina B.
Perez-Plasencia, Carlos
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Inst Nacl Cancerol, Lab Genom, Mexico City 14080, MexicoUniv Autonoma San Luis Potosi, Coordinac Acad Reg Altiplano, San Luis Potosi 78760, Mexico
Perez-Plasencia, Carlos
Lopez-Camarillo, Cesar
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机构:
Univ Autonoma Ciudad Mexico, Posgrad Ciencias Genom, Mexico City 03100, MexicoUniv Autonoma San Luis Potosi, Coordinac Acad Reg Altiplano, San Luis Potosi 78760, Mexico
机构:
CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science,School of Life Sciences, University of Science and Technology of ChinaCAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science,School of Life Sciences, University of Science and Technology of China