A Novel Regulatory Player in the Innate Immune System: Long Non-Coding RNAs

被引:13
|
作者
Xie, Yuhuai [1 ]
Wei, Yuanyuan [1 ,2 ]
机构
[1] Fudan Univ, Sch Basic Med Sci, Dept Immunol, Shanghai 200032, Peoples R China
[2] Fudan Univ, Sch Basic Med Sci, State Key Lab Med Neurobiol, Shanghai Key Lab Bioact Small Mol, Shanghai 200032, Peoples R China
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
long non-coding RNA; transcriptional regulation; inflammation; innate immunity; innate immune cells; NF-KAPPA-B; GENOME-WIDE ANALYSIS; GENE-EXPRESSION; CHROMATIN INTERACTIONS; INFLAMMATORY RESPONSE; MACROPHAGE ACTIVATION; MOLECULAR-MECHANISMS; PATTERN-RECOGNITION; MALAT1; CONTRIBUTES; STRANDED-RNA;
D O I
10.3390/ijms22179535
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Long non-coding RNAs (lncRNAs) represent crucial transcriptional and post-transcriptional gene regulators during antimicrobial responses in the host innate immune system. Studies have shown that lncRNAs are expressed in a highly tissue- and cell-specific-manner and are involved in the differentiation and function of innate immune cells, as well as inflammatory and antiviral processes, through versatile molecular mechanisms. These lncRNAs function via the interactions with DNA, RNA, or protein in either cis or trans pattern, relying on their specific sequences or their transcriptions and processing. The dysregulation of lncRNA function is associated with various human non-infectious diseases, such as inflammatory bowel disease, cardiovascular diseases, and diabetes mellitus. Here, we provide an overview of the regulation and mechanisms of lncRNA function in the development and differentiation of innate immune cells, and during the activation or repression of innate immune responses. These elucidations might be beneficial for the development of therapeutic strategies targeting inflammatory and innate immune-mediated diseases.
引用
收藏
页数:26
相关论文
共 50 条
  • [31] Regulatory role of long non-coding RNAs during reproductive disease
    Liu, Kangsheng
    Mao, Xiaodong
    Chen, Yajun
    Li, Taiping
    Ton, Hua
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2018, 10 (01): : 1 - 12
  • [32] Regulatory Roles of Related Long Non-coding RNAs in the Process of Atherosclerosis
    Meng, Qingyu
    Pu, Luya
    Luo, Xizi
    Wang, Baisen
    Li, Fan
    Liu, Bin
    FRONTIERS IN PHYSIOLOGY, 2020, 11
  • [33] Long non-coding RNAs: Functional regulatory players in breast cancer
    Youness, Rana Ahmed
    Gad, Mohamed Zakaria
    NON-CODING RNA RESEARCH, 2019, 4 (01): : 36 - 44
  • [34] Updates on plant long non-coding RNAs (lncRNAs): the regulatory components
    Sanchita
    Trivedi, Prabodh Kumar
    Asif, Mehar Hasan
    PLANT CELL TISSUE AND ORGAN CULTURE, 2020, 140 (02) : 259 - 269
  • [35] Epigenetic Regulation by Non-Coding RNAs in the Avian Immune System
    Chen, Xiaolan
    Abdalla, Bahareldin Ali
    Li, Zhenhui
    Nie, Qinghua
    LIFE-BASEL, 2020, 10 (08): : 1 - 24
  • [36] Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response
    Agirre, Xabier
    Meydan, Cem
    Jiang, Yanwen
    Garate, Leire
    Doane, Ashley S.
    Li, Zhuoning
    Verma, Akanksha
    Paiva, Bruno
    Martin-Subero, Jose I.
    Elemento, Olivier
    Mason, Christopher E.
    Prosper, Felipe
    Melnick, Ari
    NATURE COMMUNICATIONS, 2019, 10 (1)
  • [37] Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response
    Xabier Agirre
    Cem Meydan
    Yanwen Jiang
    Leire Garate
    Ashley S. Doane
    Zhuoning Li
    Akanksha Verma
    Bruno Paiva
    José I. Martín-Subero
    Olivier Elemento
    Christopher E. Mason
    Felipe Prosper
    Ari Melnick
    Nature Communications, 10
  • [38] Diverse roles of regulatory non-coding RNAs
    Wang, Zefeng
    JOURNAL OF MOLECULAR CELL BIOLOGY, 2018, 10 (02) : 91 - 92
  • [39] Long non-coding RNAs as novel therapeutic targets in cancer
    Lavorgna, Giovanni
    Vago, Riccardo
    Sarmini, Mohamad
    Montorsi, Francesco
    Salonia, Andrea
    Bellone, Matteo
    PHARMACOLOGICAL RESEARCH, 2016, 110 : 131 - 138
  • [40] Novel expressed long non-coding RNAs in uveal melanoma
    Rodriguez, Daniel A.
    Kuznetsov, Jeffim N.
    Sanchez, Margaret I.
    Kurtenbach, Stefan
    Harbour, J. William
    CANCER RESEARCH, 2019, 79 (13)