99mTC-sestamibi breast imaging: Current status, new ideas and future perspectives

被引：17
|
作者：
Urbano, Nicoletta [1 ]
Scimeca, Manuel [2 ,3 ,4 ,5 ]
Tancredi, Virginia [6 ,7 ]
Bonanno, Elena [8 ,9 ,10 ]
Schillaci, Orazio [2 ]
机构：
[1] Policlin Tor Vergata, Nucl Med, Viale Oxford 81, I-00133 Rome, Italy
[2] Univ Roma Tor Vergata, Dept Biomed & Prevent, Via Montpellier 1, I-00133 Rome, Italy
[3] Univ San Raffaele, Via Val Cannuta 247, I-00166 Rome, Italy
[4] Fdn Umberto Veronesi FUV, Piazza Velasca 5, I-20122 Milan, Mi, Italy
[5] St Camillus Int Univ Hlth Sci, UniCamillus, Rome, Italy
[6] Univ Roma Tor Vergata, Sch Sport & Exercise Sci, Dept Syst Med, Rome, Italy
[7] Univ Roma Tor Vergata, Ctr Space Biomed, Rome, Italy
[8] Univ Roma Tor Vergata, Dept Expt Med, Via Montpellier 1, I-00133 Rome, Italy
[9] Diagnost Med, I-83100 Avellino, Italy
[10] Neuromed Grp, Villa Platani, I-83100 Avellino, Is, Italy
来源：
SEMINARS IN CANCER BIOLOGY | 2022年 / 84卷
关键词：
99; mTC-sestamibi; Dedicated breast gamma camera; Breast cancer; Bone metastasis; Molecular imaging; BACKGROUND PARENCHYMAL UPTAKE; OSTEOBLAST-LIKE CELLS; BONE-FORMATION; CANCER; BIOPSY; TUMOR; SCINTIMAMMOGRAPHY; TC-99M-MIBI; MARKERS; MIBI;
D O I：
10.1016/j.semcancer.2020.01.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Here we proposed the most recent innovations in the use of Breast Specific Gamma Imaging with 99mTc-sestamibi for the management of breast cancer patients. To this end, we reported the recent discoveries concerning: a) the implementation of both instrumental devices and software, b) the biological mechanisms involved in the 99mTc-sestamibi uptake in breast cancer cells, c) the evaluation of Breast Specific Gamma Imaging with 99mTcsestamibi as predictive markers of metastatic diseases. In this last case, we also reported preliminary data about the capability of Breast Specific Gamma Imaging with 99mTc-sestamibi to identify breast cancer lesions with high propensity to form bone metastatic lesions due to the presence of Breast Osteoblast-Like Cells.
引用
收藏
页码：302 / 309
页数：8
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