Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS

被引：26

作者：

Steel, Christina D. ^{[1
]}

Kim, Woong-Ki ^{[1
]}

Sanford, Larry D. ^{[2
]}

Wellman, Laurie L. ^{[2
]}

Burnett, Sandra ^{[3
]}

Van Rooijen, Nico ^{[4
]}

Ciavarra, Richard P. ^{[1
]}

机构：

[1] Eastern Virginia Med Sch, Dept Microbiol & Mol & Cell Biol, Norfolk, VA 23501 USA

[2] Eastern Virginia Med Sch, Dept Anat & Pathol, Norfolk, VA 23501 USA

[3] Brigham Young Univ, Dept Microbiol & Mol Biol, Provo, UT 84602 USA

[4] Vrije Univ Amsterdam, Fac Med, Dept Mol Cell Biol, Amsterdam, Netherlands

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 226卷 / 1-2期

关键词：

Microglia; Vesicular stomatitis virus; Perivascular/meningeal macrophage; Dendritic cell; Granulocytes; Interferon gamma; CENTRAL-NERVOUS-SYSTEM; VESICULAR STOMATITIS-VIRUS; BLOOD-BRAIN-BARRIER; CD8; T-CELLS; DENDRITIC CELLS; IN-VIVO; PERIVASCULAR MACROPHAGES; MENINGEAL MACROPHAGES; ANTIVIRAL IMMUNITY; GENE-EXPRESSION;

D O I：

10.1016/j.jneuroim.2010.05.034

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intranasal application of vesicular stomatitis virus (VSV) induces acute encephalitis characterized by a pronounced myeloid and T cell infiltrate. The role of distinct phagocytic populations on VSV encephalitis was therefore examined in this study. Ablation of peripheral macrophages did not impair VSV encephalitis or viral clearance from the brain, whereas, depletion of splenic marginal dendritic cells impaired this response and enhanced morbidity/mortality. Selective depletion of brain perivascular macrophages also suppressed this response without altering viral clearance. Thus, two anatomically distinct phagocytic populations regulate VSV encephalitis in a non-redundant fashion although neither population is essential for viral clearance in the CNS. (C) 2010 Elsevier By. All rights reserved.

引用

页码：81 / 92

页数：12

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