Synthesis of Natural Products Using Intramolecular Dipolar Cycloaddition Reactions

被引：0

作者：

Burrell, Adam J. M. ^{[2
]}

Coldham, Iain ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

[2] Ringaskiddy API, Pfizer Ireland Pharmaceut, Proc Dev Ctr, Ringaskiddy, Cork, Ireland

来源：

CURRENT ORGANIC SYNTHESIS | 2010年 / 7卷 / 04期

关键词：

Cycloaddition; dipoles; natural products; synthesis; ylides; ENANTIOSELECTIVE TOTAL SYNTHESES; QUATERNARY CARBON CENTER; FUSED TRICYCLIC AMINES; 1,3-DIPOLAR CYCLOADDITION; CARBOHYDRATE MIMICS; ASYMMETRIC-SYNTHESIS; ACYCLIC ALDEHYDES; AZOMETHINE YLIDE; FORMAL SYNTHESIS; DIAZO-COMPOUNDS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This review describes ylide 1,3-dipoles in cycloaddition reactions for the synthesis (and formal synthesis) of natural products. Examples using azomethine ylides, carbonyl ylides, nitrones, nitronates, nitrile oxides and azides are provided. These lead to a diverse array of heterocyclic products. Intramolecular cycloaddition provides two new rings in one step and hence an efficient entry to complex target compounds.

引用

页码：312 / 331

页数：20

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