Immunomodulatory characteristics of mesenchymal stem cells and their role in the treatment of Multiple Sclerosis

被引：92
作者：
Gharibi, Tohid [1 ,2 ]
Ahmadi, Majid [1 ,2 ]
Seyfizadeh, Narges [1 ,2 ]
Jadidi-Niaragh, Farhad [3 ]
Yousefi, Mehdi [1 ,2 ]
机构：
[1] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Sch Med, Dept Immunol, Tabriz, Iran
[3] Tabriz Univ Med Sci, Sch Publ Hlth, Dept Immunol, Tabriz, Iran
来源：
CELLULAR IMMUNOLOGY | 2015年 / 293卷 / 02期
关键词：
Mesenchymal stem cells; Multiple Sclerosis; Immunomodulation; MARROW STROMAL CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; INHIBIT LYMPHOCYTE-PROLIFERATION; SUPPRESS T-LYMPHOCYTE; MYELIN BASIC-PROTEIN; BONE-MARROW; IN-VITRO; NEURAL PROGENITORS; INTERFERON-GAMMA;
D O I：
10.1016/j.cellimm.2015.01.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Multiple Sclerosis (MS) is a chronic inflammatory neurodegenerative disease of central nervous system (CNS). Although the main cause of MS is not clear, studies suggest that MS is an autoimmune disease which attacks myelin sheath of neurons. There are different therapeutic regimens for MS patients including interferon (IFN)-beta, glatiramer acetate (GA), and natalizumab. However, such therapies are not quite effective and are associated with some side effects. So which, there is no complete therapeutic method for MS patients. Regarding the potent immunomodulatory effects of mesenchymal stem cells (MSCs) and their ameliorative effects in experimental autoimmune encephalopathy (EAE), it seems that MSCs may be a new therapeutic method in MS therapy. MSC transplantation is an approach to regulate the immune system in the region of CNS lesions. In this review, we have tried to discuss about the immunomodulatory properties of MSCs and their therapeutic mechanisms in MS patients. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：113 / 121
页数：9
相关论文
共 160 条
[1]   Human mesenchymal stem cells modulate allogeneic immune cell responses [J].
Aggarwal, S ;
Pittenger, MF .
BLOOD, 2005, 105 (04) :1815-1822
[2]  
Angoulvant D, 2004, BIORHEOLOGY, V41, P469
[3]   Neuroprotection with glatiramer acetate: evidence from the PreCISe trial [J].
Arnold, Douglas L. ;
Narayanan, Sridar ;
Antel, Samson .
JOURNAL OF NEUROLOGY, 2013, 260 (07) :1901-1906
[4]   Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway [J].
Augello, A ;
Tasso, R ;
Negrini, SM ;
Amateis, A ;
Indiveri, F ;
Cancedda, R ;
Pennesi, G .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (05) :1482-1490
[5]  
Auletta JJ, 2012, IMMUNOTHERAPY-UK, V4, P529, DOI [10.2217/IMT.12.41, 10.2217/imt.12.41]
[6]   Regenerative Stromal Cell Therapy in Allogeneic Hematopoietic Stem Cell Transplantation: Current Impact and Future Directions [J].
Auletta, Jeffery J. ;
Cooke, Kenneth R. ;
Solchaga, Luis A. ;
Deans, Robert J. ;
van't Hof, Wouter .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2010, 16 (07) :891-906
[7]   Hepatocyte growth factor mediates mesenchymal stem cell-induced recovery in multiple sclerosis models [J].
Bai, Lianhua ;
Lennon, Donald P. ;
Caplan, Arnold I. ;
DeChant, Anne ;
Hecker, Jordan ;
Kranso, Janet ;
Zaremba, Anita ;
Miller, Robert H. .
NATURE NEUROSCIENCE, 2012, 15 (06) :862-U86
[8]   Human Bone Marrow-Derived Mesenchymal Stem Cells Induce Th2-Polarized Immune Response and Promote Endogenous Repair in Animal Models of Multiple Sclerosis [J].
Bai, Lianhua ;
Lennon, Donald P. ;
Eaton, Valerie ;
Maier, Kari ;
Caplan, Arnold I. ;
Miller, Stephen D. ;
Miller, Robert H. .
GLIA, 2009, 57 (11) :1192-1203
[9]   Intracerebroventricular Transplantation of Human Mesenchymal Stem Cells Induced to Secrete Neurotrophic Factors Attenuates Clinical Symptoms in a Mouse Model of Multiple Sclerosis [J].
Barhum, Yael ;
Gai-Castro, Sharon ;
Bahat-Stromza, Merav ;
Barzilay, Ran ;
Melamed, Eldad ;
Offen, Daniel .
JOURNAL OF MOLECULAR NEUROSCIENCE, 2010, 41 (01) :129-137
[10]   Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness [J].
Beyth, S ;
Borovsky, Z ;
Mevorach, D ;
Liebergall, M ;
Gazit, Z ;
Aslan, H ;
Galun, E ;
Rachmilewitz, J .
BLOOD, 2005, 105 (05) :2214-2219
12345678910