Linking Long Noncoding RNA Localization and Function

被引：863

作者：

Chen, Ling-Ling ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Mol Biol,Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci,Shanghai Key Lab, Shanghai, Peoples R China

[2] Shanghai Tech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai, Peoples R China

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2016年 / 41卷 / 09期

关键词：

MESSENGER-RNAS; CHROMATIN INTERACTIONS; NUCLEAR PARASPECKLES; CANCER METASTASIS; BINDING PROTEINS; GENE-EXPRESSION; CIRCULAR RNAS; BREAST-CANCER; TRIPLE-HELIX; XIST RNA;

D O I：

10.1016/j.tibs.2016.07.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have revealed the regulatory potential of many long noncoding RNAs (IncRNAs). Most IncRNAs, like mRNAs, are transcribed by RNA polymerase II and are capped, polyadenylated, and spliced. However, the subcellular fates of IncRNAs are distinct and the mechanisms of action are diverse. Investigating the mechanisms that determine the subcellular fate of IncRNAs has the potential to provide new insights into their biogenesis and specialized functions.

引用

页码：761 / 772

页数：12

共 88 条

[61] RNA Exosome Depletion Reveals Transcription Upstream of Active Human Promoters [J].

Preker, Pascal ;

Nielsen, Jesper ;

Kammler, Susanne ;

Lykke-Andersen, Soren ;

Christensen, Marianne S. ;

Mapendano, Christophe K. ;

Schierup, Mikkel H. ;

Jensen, Torben Heick .

SCIENCE, 2008, 322 (5909) :1851-1854

[62] Unique features of long non-coding RNA biogenesis and function [J].

Quinn, Jeffrey J. ;

Chang, Howard Y. .

NATURE REVIEWS GENETICS, 2016, 17 (01) :47-62

[63] Genome-wide structure and organization of eukaryotic pre-initiation complexes [J].

Rhee, Ho Sung ;

Pugh, B. Franklin .

NATURE, 2012, 483 (7389) :295-301

[64] Functional demarcation of active and silent chromatin domains in human HOX loci by Noncoding RNAs [J].

Rinn, John L. ;

Kertesz, Michael ;

Wang, Jordon K. ;

Squazzo, Sharon L. ;

Xu, Xiao ;

Brugmann, Samantha A. ;

Goodnough, L. Henry ;

Helms, Jill A. ;

Farnham, Peggy J. ;

Segal, Eran ;

Chang, Howard Y. .

CELL, 2007, 129 (07) :1311-1323

[65] Genome Regulation by Long Noncoding RNAs [J].

Rinn, John L. ;

Chang, Howard Y. .

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81, 2012, 81 :145-166

[66] MENε/β noncoding RNAs are essential for structural integrity of nuclear paraspeckles [J].

Sasaki, Yasnory T. F. ;

Ideue, Takashi ;

Sano, Miho ;

Mituyama, Toutai ;

Hirose, Tetsuro .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (08) :2525-2530

[67] Transcription factor trapping by RNA in gene regulatory elements [J].

Sigova, Alla A. ;

Abraham, Brian J. ;

Ji, Xiong ;

Molinie, Benoit ;

Hannett, Nancy M. ;

Guo, Yang Eric ;

Jangi, Mohini ;

Giallourakis, Cosmas C. ;

Sharp, Phillip A. ;

Young, Richard A. .

SCIENCE, 2015, 350 (6263) :978-981

[68] HOTAIR Forms an Intricate and Modular Secondary Structure [J].

Somarowthu, Srinivas ;

Legiewicz, Michal ;

Chillon, Isabel ;

Marcia, Marco ;

Liu, Fei ;

Pyle, Anna Marie .

MOLECULAR CELL, 2015, 58 (02) :353-361

[69] MEN ε/β nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles [J].

Sunwoo, Hongjae ;

Dinger, Marcel E. ;

Wilusz, Jeremy E. ;

Amaral, Paulo P. ;

Mattick, John S. ;

Spector, David L. .

GENOME RESEARCH, 2009, 19 (03) :347-359

[70] Polycomb Group Proteins Ezh2 and Rnf2 Direct Genomic Contraction and Imprinted Repression in Early Mouse Embryos [J].

Terranova, Rrni ;

Yokobayashi, Shihori ;

Stadler, Michael B. ;

Otte, Arie P. ;

van Lohuizen, Maarten ;

Orkin, Stuart H. ;

Peters, Antoine H. F. M. .

DEVELOPMENTAL CELL, 2008, 15 (05) :668-679

← 1 2 3 4 5 6 7 8 9 →