Linking Long Noncoding RNA Localization and Function

被引：839
作者：
Chen, Ling-Ling [1 ,2 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Mol Biol,Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci,Shanghai Key Lab, Shanghai, Peoples R China
[2] Shanghai Tech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai, Peoples R China
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2016年 / 41卷 / 09期
关键词：
MESSENGER-RNAS; CHROMATIN INTERACTIONS; NUCLEAR PARASPECKLES; CANCER METASTASIS; BINDING PROTEINS; GENE-EXPRESSION; CIRCULAR RNAS; BREAST-CANCER; TRIPLE-HELIX; XIST RNA;
D O I：
10.1016/j.tibs.2016.07.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent studies have revealed the regulatory potential of many long noncoding RNAs (IncRNAs). Most IncRNAs, like mRNAs, are transcribed by RNA polymerase II and are capped, polyadenylated, and spliced. However, the subcellular fates of IncRNAs are distinct and the mechanisms of action are diverse. Investigating the mechanisms that determine the subcellular fate of IncRNAs has the potential to provide new insights into their biogenesis and specialized functions.
引用
收藏
页码：761 / 772
页数：12
相关论文
共 88 条
  • [1] A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance
    Anderson, Douglas M.
    Anderson, Kelly M.
    Chang, Chi-Lun
    Makarewich, Catherine A.
    Nelson, Benjamin R.
    McAnally, John R.
    Kasaragod, Prasad
    Shelton, John M.
    Liou, Jen
    Bassel-Duby, Rhonda
    Olson, Eric N.
    [J]. CELL, 2015, 160 (04) : 595 - 606
  • [2] Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss
    Arun, Gayatri
    Diermeier, Sarah
    Akerman, Martin
    Chang, Kung-Chi
    Wilkinson, J. Erby
    Hearn, Stephen
    Kim, Youngsoo
    MacLeod, A. Robert
    Krainer, Adrian R.
    Norton, Larry
    Brogi, Edi
    Egeblad, Mikala
    Spector, David L.
    [J]. GENES & DEVELOPMENT, 2016, 30 (01) : 34 - 51
  • [3] Long Noncoding RNAs: Cellular Address Codes in Development and Disease
    Batista, Pedro J.
    Chang, Howard Y.
    [J]. CELL, 2013, 152 (06) : 1298 - 1307
  • [4] Assembly, disassembly and recycling The dynamics of exon junction complexes
    Bono, Fulvia
    Gehring, Niels H.
    [J]. RNA BIOLOGY, 2011, 8 (01) : 24 - 29
  • [5] Formation of triple-helical structures by the 3′-end sequences of MALAT1 and MENβ noncoding RNAs
    Brown, Jessica A.
    Valenstein, Max L.
    Yario, Therese A.
    Tycowski, Kazimierz T.
    Steitz, Joan A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (47) : 19202 - 19207
  • [6] Localization and abundance analysis of human IncRNAs at single-cell and single-molecule resolution
    Cabili, Moran N.
    Dunagin, Margaret C.
    McClanahan, Patrick D.
    Biaesch, Andrew
    Padovan-Merhar, Olivia
    Regev, Aviv
    Rinn, John L.
    Raj, Arjun
    [J]. GENOME BIOLOGY, 2015, 16
  • [7] Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses
    Cabili, Moran N.
    Trapnell, Cole
    Goff, Loyal
    Koziol, Magdalena
    Tazon-Vega, Barbara
    Regev, Aviv
    Rinn, John L.
    [J]. GENES & DEVELOPMENT, 2011, 25 (18) : 1915 - 1927
  • [8] A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA
    Cesana, Marcella
    Cacchiarelli, Davide
    Legnini, Ivano
    Santini, Tiziana
    Sthandier, Olga
    Chinappi, Mauro
    Tramontano, Anna
    Bozzoni, Irene
    [J]. CELL, 2011, 147 (02) : 358 - 369
  • [9] The biogenesis and emerging roles of circular RNAs
    Chen, Ling-Ling
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2016, 17 (04) : 205 - 211
  • [10] Decoding the function of nuclear long non-coding RNAs
    Chen, Ling-Ling
    Carmichael, Gordon G.
    [J]. CURRENT OPINION IN CELL BIOLOGY, 2010, 22 (03) : 357 - 364
123456789