Linking Long Noncoding RNA Localization and Function

被引：863

作者：

Chen, Ling-Ling ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Mol Biol,Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci,Shanghai Key Lab, Shanghai, Peoples R China

[2] Shanghai Tech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai, Peoples R China

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2016年 / 41卷 / 09期

关键词：

MESSENGER-RNAS; CHROMATIN INTERACTIONS; NUCLEAR PARASPECKLES; CANCER METASTASIS; BINDING PROTEINS; GENE-EXPRESSION; CIRCULAR RNAS; BREAST-CANCER; TRIPLE-HELIX; XIST RNA;

D O I：

10.1016/j.tibs.2016.07.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have revealed the regulatory potential of many long noncoding RNAs (IncRNAs). Most IncRNAs, like mRNAs, are transcribed by RNA polymerase II and are capped, polyadenylated, and spliced. However, the subcellular fates of IncRNAs are distinct and the mechanisms of action are diverse. Investigating the mechanisms that determine the subcellular fate of IncRNAs has the potential to provide new insights into their biogenesis and specialized functions.

引用

页码：761 / 772

页数：12

共 88 条

[1] A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance [J].

Anderson, Douglas M. ;

Anderson, Kelly M. ;

Chang, Chi-Lun ;

Makarewich, Catherine A. ;

Nelson, Benjamin R. ;

McAnally, John R. ;

Kasaragod, Prasad ;

Shelton, John M. ;

Liou, Jen ;

Bassel-Duby, Rhonda ;

Olson, Eric N. .

CELL, 2015, 160 (04) :595-606

[2] Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss [J].

Arun, Gayatri ;

Diermeier, Sarah ;

Akerman, Martin ;

Chang, Kung-Chi ;

Wilkinson, J. Erby ;

Hearn, Stephen ;

Kim, Youngsoo ;

MacLeod, A. Robert ;

Krainer, Adrian R. ;

Norton, Larry ;

Brogi, Edi ;

Egeblad, Mikala ;

Spector, David L. .

GENES & DEVELOPMENT, 2016, 30 (01) :34-51

[3] Long Noncoding RNAs: Cellular Address Codes in Development and Disease [J].

Batista, Pedro J. ;

Chang, Howard Y. .

CELL, 2013, 152 (06) :1298-1307

[4] Assembly, disassembly and recycling The dynamics of exon junction complexes [J].

Bono, Fulvia ;

Gehring, Niels H. .

RNA BIOLOGY, 2011, 8 (01) :24-29

[5] Formation of triple-helical structures by the 3′-end sequences of MALAT1 and MENβ noncoding RNAs [J].

Brown, Jessica A. ;

Valenstein, Max L. ;

Yario, Therese A. ;

Tycowski, Kazimierz T. ;

Steitz, Joan A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (47) :19202-19207

[6] Localization and abundance analysis of human IncRNAs at single-cell and single-molecule resolution [J].

Cabili, Moran N. ;

Dunagin, Margaret C. ;

McClanahan, Patrick D. ;

Biaesch, Andrew ;

Padovan-Merhar, Olivia ;

Regev, Aviv ;

Rinn, John L. ;

Raj, Arjun .

GENOME BIOLOGY, 2015, 16

[7] Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses [J].

Cabili, Moran N. ;

Trapnell, Cole ;

Goff, Loyal ;

Koziol, Magdalena ;

Tazon-Vega, Barbara ;

Regev, Aviv ;

Rinn, John L. .

GENES & DEVELOPMENT, 2011, 25 (18) :1915-1927

[8] A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA [J].

Cesana, Marcella ;

Cacchiarelli, Davide ;

Legnini, Ivano ;

Santini, Tiziana ;

Sthandier, Olga ;

Chinappi, Mauro ;

Tramontano, Anna ;

Bozzoni, Irene .

CELL, 2011, 147 (02) :358-369

[9] The biogenesis and emerging roles of circular RNAs [J].

Chen, Ling-Ling .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2016, 17 (04) :205-211

[10] Decoding the function of nuclear long non-coding RNAs [J].

Chen, Ling-Ling ;

Carmichael, Gordon G. .

CURRENT OPINION IN CELL BIOLOGY, 2010, 22 (03) :357-364

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