Oxidative Stress and NADPH Oxidase: Connecting Electromagnetic Fields, Cation Channels and Biological Effects

被引：25

作者：

Georgiou, Christos D. ^{[1
]}

Margaritis, Lukas H. ^{[2
]}

机构：

[1] Univ Patras, Dept Biol, Sect Genet Cell & Dev Biol, Patras 10679, Greece

[2] Natl & Kapodistrian Univ Athens, Dept Biol, Sect Cell Biol & Biophys, Athens 26504, Greece

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 18期

关键词：

EMF; voltage-gated calcium channels; cation channels; ROS; DNA damage; carcinogenesis; MOBILE-PHONE RADIATION; GATED PROTON CHANNELS; DNA-DAMAGE; RADIOFREQUENCY RADIATION; DROSOPHILA OOGENESIS; HYDROGEN-PEROXIDE; RADICAL PAIR; ION CHANNELS; SHORT-TERM; SUPEROXIDE;

D O I：

10.3390/ijms221810041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Electromagnetic fields (EMFs) disrupt the electrochemical balance of biological membranes, thereby causing abnormal cation movement and deterioration of the function of membrane voltage-gated ion channels. These can trigger an increase of oxidative stress (OS) and the impairment of all cellular functions, including DNA damage and subsequent carcinogenesis. In this review we focus on the main mechanisms of OS generation by EMF-sensitized NADPH oxidase (NOX), the involved OS biochemistry, and the associated key biological effects.

引用

页数：10

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