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Shope fibroma virus RING finger protein N1R binds DNA and inhibits apoptosis
被引:38
作者:

Brick, DJ
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机构: Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8W 3P6, Canada

Burke, RD
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机构: Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8W 3P6, Canada

Schiff, L
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机构: Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8W 3P6, Canada

Upton, C
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机构: Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8W 3P6, Canada
机构:
[1] Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8W 3P6, Canada
[2] Univ Victoria, Dept Biol, Victoria, BC V8W 3P6, Canada
[3] Univ Minnesota, Dept Microbiol, Minneapolis, MN 55455 USA
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D O I:
10.1006/viro.1998.9304
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Shope fibroma virus (SFV) N1R gene encodes a RING finger protein that localizes to virus factories within the cytoplasm of infected cells. Altered proteins, with deletions and site-specific mutations, were transiently expressed in vaccinia virus-infected cells to discern regions of the protein that are required for localization. We have determined that at least part of the RING finger region is necessary for localization but that the RING motif alone is not sufficient. A chimeric protein, however, in which the RING finger region of the herpes simplex virus-1 ICP0 protein replaces the SFV N1R RING motif does localize to virus factories, A region of five highly conserved amino acids at the amino terminus of SFV N1R is also critical for localization. We report that the SFV N1R protein binds double- and single-stranded DNA, suggesting a mechanism for localization, and that overexpression of this protein in vaccinia virus-infected cells reduces apoptosis-associated fragmentation of nuclear DNA. (C) 1998 Academic Press.
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页码:42 / 51
页数:10
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