14-3-3 Proteins in Brain Development: Neurogenesis, Neuronal Migration and Neuromorphogenesis

被引:95
作者
Cornell, Brett [1 ]
Toyo-Oka, Kazuhito [1 ]
机构
[1] Drexel Univ, Coll Med, Dept Neurobiol & Anat, Philadelphia, PA 19104 USA
关键词
14-3-3; proteins; neurogenesis; neuronal migration; neuromorphogenesis; synaptogenesis; neurite initiation; neurite growth; neurodevelopmental disorders; CELL-CYCLE; STRUCTURAL BASIS; CRYSTAL-STRUCTURE; TRYPTOPHAN; 5-MONOOXYGENASE; TYROSINE; 3-MONOOXYGENASE; SUBCELLULAR-LOCALIZATION; NEURAL PRECURSORS; PROGENITOR CELLS; EXOENZYME-S; BINDING;
D O I
10.3389/fnmol.2017.00318
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The 14-3-3 proteins are a family of highly conserved, multifunctional proteins that are highly expressed in the brain during development. Cumulatively, the seven 14-3-3 isoforms make up approximately 1% of total soluble brain protein. Over the last decade, evidence has accumulated implicating the importance of the 14-3-3 protein family in the development of the nervous system, in particular cortical development, and have more recently been recognized as key regulators in a number of neurodevelopmental processes. In this review we will discuss the known roles of each 14-3-3 isoform in the development of the cortex, their relation to human neurodevelopmental disorders, as well as the challenges and questions that are left to be answered. In particular, we focus on the 14-3-3 isoforms and their involvement in the three key stages of cortical development; neurogenesis and differentiation, neuronal migration and neuromorphogenesis and synaptogenesis.
引用
收藏
页数:17
相关论文
共 150 条
[1]   14-3-3 connects glycogen synthase kinase-3β to tau within a brain microtubule-associated tau phosphorylation complex [J].
Agarwal-Mawal, A ;
Qureshi, HY ;
Cafferty, PW ;
Yuan, ZF ;
Han, D ;
Lin, RT ;
Paudet, HK .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (15) :12722-12728
[2]  
AITKEN A, 1990, NATURE, V344, P594
[3]   Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variants. [J].
Aitken, A .
PLANT MOLECULAR BIOLOGY, 2002, 50 (06) :993-1010
[4]   14-3-3 proteins: A historic overview [J].
Aitken, Alastair .
SEMINARS IN CANCER BIOLOGY, 2006, 16 (03) :162-172
[5]   Post-translational modification of 14-3-3 isoforms and regulation of cellular function [J].
Aitken, Alastair .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2011, 22 (07) :673-680
[6]   CDNA CLONING AND CHARACTERIZATION OF MITOCHONDRIAL IMPORT STIMULATION FACTOR (MSF) PURIFIED FROM RAT-LIVER CYTOSOL [J].
ALAM, R ;
HACHIYA, N ;
SAKAGUCHI, M ;
KAWABATA, S ;
IWANAGA, S ;
KITAJIMA, M ;
MIHARA, K ;
OMURA, T .
JOURNAL OF BIOCHEMISTRY, 1994, 116 (02) :416-425
[7]   A Microduplication on Chromosome 17p13.1p13.3 Including the PAFAH1B1 (LIS1) Gene [J].
Avela, Kristiina ;
Aktan-Collan, Katja ;
Horelli-Kuitunen, Nina ;
Knuutila, Sakari ;
Somer, Mirja .
AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2011, 155A (04) :875-879
[8]   The crystal structure of the non-liganded 14-3-3σ protein:: insights into determinants of isoform specific ligand binding and dimerization [J].
Benzinger, A ;
Popowicz, GM ;
Joy, JK ;
Majumdar, S ;
Holak, TA ;
Hermeking, H .
CELL RESEARCH, 2005, 15 (04) :219-227
[9]   14-3-3 proteins in the nervous system [J].
Berg, D ;
Holzmann, C ;
Riess, O .
NATURE REVIEWS NEUROSCIENCE, 2003, 4 (09) :752-762
[10]   Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3ζ [J].
Birkenfeld, J ;
Betz, H ;
Roth, D .
BIOCHEMICAL JOURNAL, 2003, 369 :45-54