Comparison of 400 mcg buccal and 400 mcg sublingual misoprostol after mifepristone medical abortion through 63 days' LMP a randomized controlled trial

被引：20

作者：

Raghavan, Sheila ^{[1
]}

Comendant, Rodica ^{[2
]}

Digol, Irena ^{[2
]}

Ungureanu, Sergiu ^{[2
]}

Dondiuc, Iurie ^{[2
]}

Turcanu, Steliana ^{[2
]}

Winikoff, Beverly ^{[1
]}

机构：

[1] Gynu Hlth Projects, New York, NY 10010 USA

[2] State Med & Pharm Univ, Municipal Clin Hosp 1, Kishinev 2001, Moldova

来源：

CONTRACEPTION | 2010年 / 82卷 / 06期

关键词：

Medical abortion; Mifepristone; Misoprostol; Buccal; Sublingual; 9 WEEKS GESTATION; VAGINAL MISOPROSTOL; ORAL MISOPROSTOL; TERMINATION; PREGNANCY; EXPERIENCES; REGIMENS; COMBINATION; TUNISIA; ROUTES;

D O I：

10.1016/j.contraception.2010.05.013

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Background Buccal misoprostol 800 mcg and sublingual misoprostol 400 mcg demonstrate high efficacy and few adverse effects when used with 200 mg mifepristone for medical abortion through 63 days since the last menstrual period (LMP) Little is known about a 400-mcg buccal dose This study compares two in-the-mouth routes of misoprostol using the same dose Study Design Eligible and consenting women (n=550) were randomized to 400 mcg of misoprostol buccally or sublingually 24 h after ingestion of 200 mg of mifepristone Abortion status was assessed 2 weeks later Results Complete abortion occurred in 97 1% of the buccal group and 97 4% of the sublingual group (p=97 RR 1 00 95% CI=0 97-1 03) Adverse effects were similar in both groups Over 90% of women in both arms expressed high satisfaction with the method Conclusions Both 400 mcg buccal misoprostol and 400 mcg sublingual misoprostol after mifepristone appear to be good options for medical abortion through 63 days' LMP (C) 2010 Elsevier Inc All rights reserved

引用

页码：513 / 519

页数：7

共 25 条

[1]

*ACOG, 2005, OBSTET GYNECOL, P871

[2] Increasing women's choices in medical abortion: A study of misoprostol 400g swallowed immediately or held sublingually following 200mg mifepristone [J].