Pituitary adenylate cyclase-activating peptide (PACAP) and its receptors in Mus musculus testis

被引：10
|
作者：
Prisco, Marina [1 ]
Rosati, Luigi [1 ]
Morgillo, Eliana [1 ]
Mollica, Maria Pina [1 ]
Agnese, Marisa [1 ]
Andreuccetti, Piero [1 ]
Valiante, Salvatore [1 ]
机构：
[1] Univ Naples Federico II, Dept Biol, Monte St Angelo Univ Campus,Via Cinthia,Ed 7, I-80126 Naples, Italy
来源：
GENERAL AND COMPARATIVE ENDOCRINOLOGY | 2020年 / 286卷
关键词：
Pituitary adenylate cydase-activating peptide (PACAP); PACAP receptors; Male gametogenesis control; Mus musculus; POLYPEPTIDE PACAP; TISSUE DISTRIBUTION; TORPEDO-MARMORATA; PAC(1) RECEPTOR; KEY PLAYER; RAT TESTIS; LOCALIZATION; EXPRESSION; VIP; STEROIDOGENESIS;
D O I：
10.1016/j.ygcen.2019.113297
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
To enlighten the involvement of PACAP/receptors system in the control of mammal testis, we investigated the expression of PACAP and the localization of PACAP and its receptors PAC1, VPAC1, and VPAC2 in the testis of Mus musculus. By molecular and immunohistochemical investigations, we highlighted that PACAP and its receptors are widely represented in germ cells of Mus testis, particularly in spermatocytes I, spermatids, and spermatozoa, strongly suggesting their involvement in spermatogenesis process. Moreover, for the first time in the adult mouse testis we highlighted that PACAP is present within Leydig cells, as PACAP receptors, confirming its involvement in the control of steroidogenesis in mouse.
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页数：6
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