Synthesis and structure of functionalized podands containing 4,7-dihydrotetrazolo[1,5-a]pyrimidine ring. Differently substituted dihydropyrimidine podands

被引：4

作者：

Filatova, Elena S. ^{[1
,2
]}

Fedorova, Olga V. ^{[1
]}

Slepukhin, Pavel A. ^{[1
,2
]}

Rusinov, Gennady L. ^{[1
,2
]}

Charushin, Valery N. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Ural Branch, I Ya Postovsky Inst Organ Synth, 22 S Kovalevskoi,20 Akad Skaya St, Ekaterinburg 620990, Russia

[2] Ural Fed Univ, 19 Mira St, Ekaterinburg 620002, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2018年 / 54卷 / 10期

基金：

俄罗斯科学基金会;

关键词：

dihydropyrimidine thione podands; 4,7-dihydrotetrazolo[1,5-a]pyrimidine podands; differently substituted podands; transport polyether spacer; Biginelli reaction;

D O I：

10.1007/s10593-018-2373-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of 3-oxobutanoate-containing polyethers with benzaldehyde and 5-aminotetrazole in the presence of polyphosphoric acid was used to synthesize podands containing two terminal tetrazolo[1,5-a] dihydropyrimidine groups. Byproducts were isolated and identified as podands containing different substituents - one 4,7-dihydrotetrazolo[1,5-a] pyrimidine ring system and a free hydroxy group at the other terminus of the polyether chain. Analogous differently substituted podands, including one 3,4-dihydropyrimidine-2(1H)-thione moiety, were isolated from the reactions of 3-oxobutanoate-containing polyethers with benzaldehyde and thiourea.

引用

页码：971 / 976

页数：6

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