Polymer-free amphilimus-eluting stent versus biodegradable polymer biolimus-eluting stent in patients with and without diabetes mellitus

被引：12

作者：

Godino, Cosmo ^{[1
]}

Pivato, Carlo Andrea ^{[1
]}

Chiarito, Mauro ^{[2
]}

Donahue, Michael ^{[3
]}

Testa, Luca ^{[4
]}

Colantonio, Riccardo ^{[5
]}

Cappelletti, Alberto ^{[1
]}

Milazzo, Diego ^{[6
]}

Parisi, Rosario ^{[7
]}

Nicolino, Annamaria ^{[8
]}

Moshiri, Shahram ^{[8
]}

Aprigliano, Gianfranco ^{[9
]}

Palloshi, Altin ^{[9
]}

Parenti, Dennis Zavalloni ^{[2
]}

Rutigliano, David ^{[10
]}

Locuratolo, Nicola ^{[10
]}

Melillo, Francesco ^{[1
]}

Scotti, Andrea ^{[1
]}

Arrigoni, Luca ^{[1
]}

Montorfano, Matteo ^{[1
]}

Fattori, Rossella ^{[7
]}

Presbitero, Patrizia ^{[2
]}

Sardella, Gennaro ^{[11
]}

Bedogni, Francesco ^{[4
]}

Margonato, Alberto ^{[1
]}

Briguori, Carlo ^{[3
]}

Colombo, Antonio ^{[1
,12
]}

机构：

[1] Ist Sci San Raffaele, Milan, Italy

[2] Humanitas Clin Inst, Milan, Italy

[3] Clin Mediterranea, Naples, Italy

[4] IRCCS Policlin San Donato, Milan, Italy

[5] Osped San Pietro FBF, Rome, Italy

[6] Osped San Giovanni Dio, Agrigento, Italy

[7] Osped Riuniti Marche Nord, Pesaro, Italy

[8] Osped Santa Corona, Pietra Ligure, Italy

[9] Ist Clin Citta Studi, Milan, Italy

[10] Osped San Paolo, Bari, Italy

[11] Univ Roma La Sapienza, Policlin Umberto I, Rome, Italy

[12] EMO GVM Ctr Cuore Columbus, Milan, Italy

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2017年 / 245卷

关键词：

Diabetes mellitus; Percutaneous coronary intervention; Polymer-free amphilimus eluting stent; Biodegradable polymer biolimus eluting stent; PERCUTANEOUS CORONARY INTERVENTION; 5-YEAR CLINICAL-OUTCOMES; DURABLE POLYMER; ASTUTE REGISTRY; POOLED ANALYSIS; EVEROLIMUS; POPULATION; RESTENOSIS; INSIGHT; DISEASE;

D O I：

10.1016/j.ijcard.2017.06.028

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: This study sought to compare clinical outcome of polymer-free amphilimus-eluting stent (PF-AES) versus biodegradable-polymer biolimus- eluting stent (BD-BES) in "all-comer" diabetes mellitus (DM) and non-DM patients who underwent percutaneous coronary intervention. Background: The PF-AES has shown promising preliminary results in patients with DM. Methods: Data from 2 multicentre-national registries (the ASTUTE and the INSPIRE-1) were used to analyse 1776 patients stratified in non-DM and DM. A double 1: 1 propensity-score matched analysis (PF-AES vs. BD-BES) was performed in each group to adjust for clinical and procedural characteristics. Primary stent-efficacy and stentsafety endpoints were 1-year target-lesion revascularization (TLR) and target-lesion failure (TLF, composed of cardiac-death, target-vessel myocardial infarction and any TLR). Results: After propensity-score matching, 850 patients were stratified as non-DM (425 PF-AES/425 BD-BES) and 480 as DM patients (240 PF-AES/240BD-BES). Both TLF (20 of 425 [5%] vs. 24 of 425 [ 6%]; Plog-rank = 0.527) and TLR (9 of 425 [2%] vs. 18 of 425 [4%]; Plog-rank= 0.079) were similar between PF-AES and BD-BES in non-DM patients. In DM, TLF (12 of 240 [5%] vs. 31 of 240 [13%]; Plog-rank= 0.002) and TLR (9 of 240 [4%] vs. 21 of 240 [9%]; Plog-rank= 0.019) were significantly lower in PF-AES compared to BD-BES. Upon multivariate analysis, the most powerful predictors of TLF were chronic kidney disease in non-DM (OR 4.24, 95% CI: 2.07-8.70, p = 0.001) and stent type in DM patients (OR 2.76, 1.36-5.56, p = 0.005). Conclusions: This matched-cohort study suggests that PF-AES has better safety and efficacy profile than BD-BES in patients with DM. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：69 / 76

页数：8

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