Unchain my heart: the scientific foundations of cardiac repair

被引：502
作者：
Dimmeler, S
Zeiher, AM
Schneider, MD
机构：
[1] Goethe Univ Frankfurt, Dept Internal Med 4, Div Mol Cardiol, D-60590 Frankfurt, Germany
[2] Baylor Coll Med, Ctr Cardiovasc Dev, Dept Med, Houston, TX USA
[3] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX USA
[4] Baylor Coll Med, Dept Physiol & Mol Biophys, Houston, TX USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 03期
关键词：
D O I：
10.1172/JCI200524283
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In humans, the biological limitations to cardiac regenerative growth create both a clinical imperative - to offset cell death in acute ischemic injury and chronic heart failure - and a clinical opportunity; that is, for using cells, genes, and proteins to rescue cardiac muscle cell number or in other ways promote more efficacious cardiac repair. Recent experimental studies and early-phase clinical trials lend credence to the visionary goal of enhancing cardiac repair as an achievable therapeutic target.
引用
收藏
页码：572 / 583
页数：12
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