Vitamin D deficiency: concern for rheumatoid arthritis and COVID-19?

被引：5

作者：

Verma, Sneha ^{[1
]}

Chaturvedi, Ved ^{[2
]}

Ganguly, N. K. ^{[1
]}

Mittal, Shivani Arora ^{[1
]}

机构：

[1] Sir Ganga Ram Hosp, Dept Res, New Delhi, India

[2] Sir Ganga Ram Hosp, Dept Rheumatol & Clin Immunol, New Delhi, India

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2021年 / 476卷 / 12期

关键词：

Vitamin D; Deficiency; Association; Rheumatoid arthritis; COVID-19; Supplementation; DISEASE-ACTIVITY; D SUPPLEMENTATION; RECEPTOR; INTERLEUKIN-6; PREVENTION; RISK; GENE;

D O I：

10.1007/s11010-021-04245-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vitamin D is an immunomodulatory hormone with an established role in calcium and phosphate metabolism and skeletal mineralization. Evidence showing its immunological benefits by regulating essential components of the innate and adaptive immune system is prevalent. Vitamin D deficiency is reported worldwide and is thereby found to be associated with various immune-related diseases. Rheumatoid Arthritis and COVID-19 are two such diseases, sharing a similar hyperinflammatory response. Various studies have found an association of lower Vitamin D levels to be associated with both these diseases. However, contrasting data is also reported. We review here the available scientific data on risk factor association and supplementation benefits of Vitamin D in Rheumatoid Arthritis and COVID-19, intending to critically evaluate the literature.

引用

页码：4351 / 4362

页数：12

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