Eosinophil polyunsaturated fatty acid metabolism and its potential control of inflammation and allergy

被引:27
|
作者
Arita, Makoto [1 ,2 ,3 ]
机构
[1] RIKEN Ctr Integrat Med Sci, Lab Metabol, Yokohama, Kanagawa, Japan
[2] Yokohama City Univ, Grad Sch Med Life Sci, Yokohama, Kanagawa, Japan
[3] Keio Univ, Grad Sch Pharmaceut Sci, Div Physiol Chem & Metab, Tokyo, Japan
基金
日本科学技术振兴机构;
关键词
Eosinophil; Lipid mediator; Lipidomics; Lipoxygenase; n-3 fatty acid;
D O I
10.1016/j.alit.2016.05.010
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Polyunsaturated fatty acids (PUFAs) exhibit a range of biological effects, many of which are mediated through the formation and actions of their bioactive metabolites. It is well appreciated that dietary PUFA balance affects inflammation and/or allergic diseases, and recent advances in liquid chromatography tandem mass spectrometry (LC-MS/MS)-based mediator lipidomics have revealed a potential link between PUFA metabolism and biological phenotypes. This review presents insights into the emerging roles of eosinophil PUFA metabolism in controlling inflammatory responses and its potential involvement in allergy control. Copyright (C) 2016, Japanese Society of Allergology. Production and hosting by Elsevier B.V.
引用
收藏
页码:S2 / S5
页数:4
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