CMV in the gut: a critical review of CMV detection in the immunocompetent host with colitis

被引:41
作者
Goodman, A. L. [1 ]
Murray, C. D. [3 ]
Watkins, J. [4 ]
Griffiths, P. D. [2 ]
Webster, D. P. [2 ]
机构
[1] UCL, Dept Infect & Immun, London WC1E 6BT, England
[2] UCL, Sch Med, Ctr Virol, London NW3 2PF, England
[3] Royal Free London NHS Fdn Trust, Dept Gastroenterol, London NW3 2QG, England
[4] Royal Free London NHS Fdn Trust, Dept Cellular Pathol, London NW3 2QG, England
关键词
INFLAMMATORY-BOWEL-DISEASE; ORGAN TRANSPLANT RECIPIENTS; ULCERATIVE-COLITIS; CYTOMEGALOVIRUS-INFECTION; GUIDELINES; KINETICS; THERAPY; ADULTS; RISK; LOAD;
D O I
10.1007/s10096-014-2212-x
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
As scientific techniques for the detection of cytomegalovirus (CMV) improve, we are able to detect small amounts of CMV in the mucosal wall. As clinicians, we are unsure how to interpret the results of this novel test. There is controversy in the literature as to the significance of the detection of CMV in the gut. Whilst the importance of CMV and reactivation of the virus is clear in those patients such as allograft recipients with established immune compromise, the role is less clear in patients with less damaged immune systems. We explore whether the detection of CMV in such cases influences outcome and how it should be optimally managed. We discuss the optimal management of such cases, according to current guidelines, with a review of the literature.
引用
收藏
页码:13 / 18
页数:6
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