Cyclotron production of Ac-225 for targeted alpha therapy

被引：115

作者：

Apostolidis, C

Molinet, R

McGinley, J

Abbas, K

Möllenbeck, J

Morgenstern, A

机构：

[1] European Commiss, Joint Res Ctr, Inst Transuranium Elements, D-76125 Karlsruhe, Germany

[2] European Commiss, Joint Res Ctr, Inst Hlth & Consumer Protect, I-21020 Ispra, Italy

[3] Forschungszentrum Karlsruhe, HZY, D-76021 Karlsruhe, Germany

来源：

APPLIED RADIATION AND ISOTOPES | 2005年 / 62卷 / 03期

关键词：

targeted alpha therapy; Actinium-225; Radium-226; cyclotron; radioisotope production;

D O I：

10.1016/j.apradiso.2004.06.013

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The feasibility of producing Ac-225 by proton irradiation of Ra-226 in a cyclotron through the reaction Ra-226(p,2n)Ac-225 has been experimentally demonstrated for the first time. Proton energies were varied from 8.8 to 24.8 MeV and cross-sections were determined by radiochemical analysis of reaction yields. Maximum yields were reached at incident proton energies of 16.8. MeV. Radiochemical separation of Ac-225 from the irradiated target yielded a product suitable for targeted alpha therapy of cancer. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：383 / 387

页数：5

共 15 条

[11] Magill J., 2003, NUCLIDES NET INTEGRA
[12] Radioimmunotherapy with alpha-emitting nuclides
McDevitt, MR
Sgouros, G
Finn, RD
Humm, JL
Jurcic, JG
Larson, SM
Scheinberg, DA
[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1998, 25 (09) : 1341 - 1351
[13] *METR GMBH, 2001, GUM GUID EXPR UNC ME
[14] MIRZADE S, 2002, P 3 ALPH IMM THER S
[15] In vitro evaluation of 213Bi-rituximab versus external gamma irradiation for the treatment of B-CLL patients:: relative biological efficacy with respect to apoptosis induction and chromosomal damage
Vandenbulcke, K
De Vos, F
Offner, F
Philippé, J
Apostolidis, C
Molinet, R
Nikula, TK
Bacher, K
de Gelder, V
Vral, A
Lahorte, C
Thierens, H
Dierckx, RA
Slegers, G
[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2003, 30 (10) : 1357 - 1364

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