Cyclotron production of Ac-225 for targeted alpha therapy

被引：115
作者：
Apostolidis, C
Molinet, R
McGinley, J
Abbas, K
Möllenbeck, J
Morgenstern, A
机构：
[1] European Commiss, Joint Res Ctr, Inst Transuranium Elements, D-76125 Karlsruhe, Germany
[2] European Commiss, Joint Res Ctr, Inst Hlth & Consumer Protect, I-21020 Ispra, Italy
[3] Forschungszentrum Karlsruhe, HZY, D-76021 Karlsruhe, Germany
来源：
APPLIED RADIATION AND ISOTOPES | 2005年 / 62卷 / 03期
关键词：
targeted alpha therapy; Actinium-225; Radium-226; cyclotron; radioisotope production;
D O I：
10.1016/j.apradiso.2004.06.013
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The feasibility of producing Ac-225 by proton irradiation of Ra-226 in a cyclotron through the reaction Ra-226(p,2n)Ac-225 has been experimentally demonstrated for the first time. Proton energies were varied from 8.8 to 24.8 MeV and cross-sections were determined by radiochemical analysis of reaction yields. Maximum yields were reached at incident proton energies of 16.8. MeV. Radiochemical separation of Ac-225 from the irradiated target yielded a product suitable for targeted alpha therapy of cancer. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：383 / 387
页数：5
相关论文
共 15 条
  • [1] Allen Barry J, 2003, Methods Mol Med, V81, P333
  • [2] Apostolidis C., 2001, NUCL NEWS, V44, P29
  • [3] BOLL RA, 2003, P 225 ACS NAT M NEW
  • [4] Feasibility of radioimmunotherapy of experimental pneumococcal infection
    Dadachova, E
    Burns, T
    Bryan, RA
    Apostolidis, C
    Brechbiel, MW
    Nosanchuk, JD
    Casadevall, A
    Pirofski, L
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (05) : 1624 - 1629
  • [5] GARLAND MA, 2003, P 225 ACS NAT M NEW
  • [6] Huber R, 2003, CLIN CANCER RES, V9, p3922S
  • [7] *ITU, 1995, 16368 ITU EUR, P55
  • [8] Targeted at particle immunotherapy for myeloid leukemia
    Jurcic, JG
    Larson, SM
    Sgouros, G
    McDevitt, MR
    Finn, RD
    Divgi, CR
    Ballangrud, ÅM
    Hamacher, KA
    Ma, DS
    Humm, JL
    Brechbiel, MW
    Molinet, R
    Scheinberg, DA
    [J]. BLOOD, 2002, 100 (04) : 1233 - 1239
  • [9] Therapy of rat tracheal carcinoma IC-12 in SCID mice:: vascular targeting with [213Bi]-MAb TES-23
    Kennel, SJ
    Lankford, T
    Davern, S
    Foote, L
    Taniguchi, K
    Ohizumi, I
    Tsutsumi, Y
    Nakagawa, S
    Mayumi, T
    Mirzadeh, S
    [J]. EUROPEAN JOURNAL OF CANCER, 2002, 38 (09) : 1278 - 1287
  • [10] LIU SF, 2003, P WORLD C MED PHYS B
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