QUANTITATIVE MUSCLE ULTRASOUND IN DUCHENNE MUSCULAR DYSTROPHY: A COMPARISON OF TECHNIQUES

被引：55

作者：

Shklyar, Irina ^{[1
]}

Geisbush, Tom R. ^{[1
]}

Mijialovic, Aleksandar S. ^{[1
]}

Pasternak, Amy ^{[2
]}

Darras, Basil T. ^{[2
]}

Wu, Jim S. ^{[3
]}

Rutkove, Seward B. ^{[1
]}

Zaidman, Craig M. ^{[4
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Neurol, Sch Med, Boston, MA 02215 USA

[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Boston Childrens Hosp, Sch Med, Boston, MA 02215 USA

[3] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Radiol, Sch Med, Boston, MA 02215 USA

[4] Washington Univ, Sch Med, Dept Neurol & Pediat, St Louis, MO 63110 USA

来源：

MUSCLE & NERVE | 2015年 / 51卷 / 02期

基金：

美国国家卫生研究院;

关键词：

biomarker; Duchenne muscular dystrophy; muscle; myopathy; ultrasound; BACKSCATTER;

D O I：

10.1002/mus.24296

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionMuscle pathology in Duchenne muscular dystrophy (DMD) can be quantified using ultrasound by measuring either the amplitudes of sound-waves scattered back from the tissue [quantitative backscatter analysis (QBA)] or by measuring these backscattered amplitudes after compression into grayscale levels (GSL) obtained from the images. Methods: We measured and compared QBA and GSL from 6 muscles of 25 boys with DMD and 25 healthy subjects, aged 2-14 years, with age and, in DMD, with function (North Star Ambulatory Assessment). Results: Both QBA and GSL were measured reliably (intraclass correlation0.87) and were higher in DMD than controls (P<0.0001). In DMD, average QBA and GSL measured from superficial regions of muscle increased (rho0.47, P<0.05) with both higher age and worse function; in contrast, GSL measured from whole regions of muscle did not. Conclusions: QBA and GSL measured from superficial regions of muscle can similarly quantify muscle pathology in DMD. Muscle Nerve 51: 207-213, 2015

引用

页码：207 / 213

页数：7

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