Synthesis and cytotoxicity of novel cholesterol-cobalt bis(dicarbollide) conjugates

被引：4
作者：
Druzina, Anna A. [1 ]
Dudarova, Nadezhda, V [1 ]
Zhidkova, Olga B. [1 ]
Razumov, Ivan A. [2 ]
Solovieva, Olga I. [2 ]
Kanygin, Vladimir V. [3 ]
Bregadze, Vladimir I. [1 ]
机构：
[1] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Moscow 119991, Russia
[2] Russian Acad Sci, Fed Res Ctr Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia
[3] Novosibirsk State Univ, Novosibirsk 630090, Russia
来源：
MENDELEEV COMMUNICATIONS | 2022年 / 32卷 / 03期
基金：
俄罗斯科学基金会;
关键词：
boron neutron capture therapy; cancer; boron cage; cobalt bis(dicarbollide); cholesterol; liposomes; lipids; cytotoxicity; human glioblastoma U-87 MG; DERIVATIVES; METALLACARBORANES; TRANSITION; LIPOSOMES; AGENTS; COSAN; IRON;
D O I：
10.1016/j.mencom.2022.05.021
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The novel conjugates of cholesterol with cobalt bis(dicarbollide) were synthesized by the ring-opening reactions of the cyclic oxonium derivatives of [3,3'-Co(C2B9H11)(2)](-) with the OH group of cholesterol 2-hydroxyethyl ether. The compounds obtained were tested for toxicity to glioblastoma U-87 MG cells and human embryo fibroblasts FECH-15 cells.
引用
收藏
页码：354 / 356
页数：3
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