A high-density genetic map of the chromosome 13q14 atopy locus

被引：13

作者：

Bhattacharyya, S ^{[1
]}

Leaves, NI ^{[1
]}

Wiltshire, S ^{[1
]}

Cox, R ^{[1
]}

Cookson, WOCM ^{[1
]}

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

来源：

GENOMICS | 2000年 / 70卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/geno.2000.6398

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Atopy describes a syndrome of immunoglobulin E (IgE)-mediated allergy that underlies asthma and infantile eczema. We have previously identified a locus on chromosome 13q14 that is linked to atopy and to the total serum immunoglobulin A concentration. We have therefore made a saturation genetic map of the region by typing 59 polymorphic microsatellite loci on chromosome 13q. Multipoint linkage analysis identified a 1-LOD support unit for the location of the atopy locus with a 7.5-cM region flanked by the loci D13S328 and D13S1269. The peak of linkage was at locus D13S161 with a nonparametric -log of P score of approximately 4.5. Parent of origin effects were present, with linkage primarily observed to paternally derived alleles. The genetic map of this region provides a basis for the effective identification of the chromosome 13 atopy gene. (C) 2000 Academic Press.

引用

页码：286 / 291

页数：6

共 33 条

[1]

Akolkar PN, 1997, AM J GASTROENTEROL, V92, P2241

[2] Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: Evidence from Afro-Caribbean and Caucasian populations [J].

Barnes, KC ;

Neely, JD ;

Duffy, DL ;

Freidhoff, LR ;

Breazeale, DR ;

Schou, C ;

Naidu, RP ;

Levett, PN ;

Renault, B ;

Kucherlapati, R ;

Iozzino, S ;

Ehrlich, E ;

Beaty, TH ;

Marsh, DG .

GENOMICS, 1996, 37 (01) :41-50

[3] Human type 1 diabetes and the insulin gene: Principles of mapping polygenes [J].

Bennett, ST ;

Todd, JA .

ANNUAL REVIEW OF GENETICS, 1996, 30 :343-370

[4]

Beyer K, 1998, J ALLERGY CLIN IMMUN, V101, pS152

[5] Comprehensive human genetic maps: Individual and sex-specific variation in recombination [J].

Broman, KW ;

Murray, JC ;

Sheffield, VC ;

White, RL ;

Weber, JL .

AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 63 (03) :861-869

[6] The alliance of genes and environment in asthma and allergy [J].

Cookson, W .

NATURE, 1999, 402 (6760) :B5-B11

[7] MATERNAL INHERITANCE OF ATOPIC IGE RESPONSIVENESS ON CHROMOSOME-11Q [J].

COOKSON, WOCM ;

YOUNG, RP ;

SANDFORD, AJ ;

MOFFATT, MF ;

SHIRAKAWA, T ;

SHARP, PA ;

FAUX, JA ;

JULIER, C ;

LESOUEF, PN ;

NAKAMURA, Y ;

LATHROP, GM ;

HOPKIN, JM .

LANCET, 1992, 340 (8816) :381-384

[8]

COOKSON WOCM, 1989, LANCET, V1, P1292

[9] A genome-wide search for quantitative trait loci underlying asthma [J].

Daniels, SE ;

Bhattacharrya, S ;

James, A ;

Leaves, NI ;

Young, A ;

Hill, MR ;

Faux, JA ;

Ryan, GF ;

leSouef, PN ;

Lathrop, GM ;

Musk, AW ;

Cookson, WOCM .

NATURE, 1996, 383 (6597) :247-250

[10]

EIBERG H, 1985, CYTOGENET CELL GENET, V40, P622

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