Prospective randomized trial of neoadjuvant chemotherapy during the 'wait period' following preoperative chemoradiotherapy for rectal cancer: results of the WAIT trial

被引：47

作者：

Moore, J. ^{[1
,2
]}

Price, T. ^{[3
]}

Carruthers, S. ^{[4
]}

Selva-Nayagam, S. ^{[5
]}

Luck, A. ^{[6
]}

Thomas, M. ^{[1
,2
]}

Hewett, P. ^{[2
,7
]}

机构：

[1] Royal Adelaide Hosp, Dept Colorectal Surg, Adelaide, SA, Australia

[2] Univ Adelaide, Dept Surg, Adelaide, SA, Australia

[3] Queen Elizabeth Hosp, Dept Med Oncol, Adelaide, SA, Australia

[4] Royal Adelaide Hosp, Dept Radiat Oncol, Adelaide, SA, Australia

[5] Royal Adelaide Hosp, Dept Med Oncol, Adelaide, SA, Australia

[6] Lyell McEwen Hlth Serv, Dept Colorectal Surg, Adelaide, SA, Australia

[7] Queen Elizabeth Hosp, Dept Colorectal Surg, Adelaide, SA, Australia

来源：

COLORECTAL DISEASE | 2017年 / 19卷 / 11期

关键词：

Rectal cancer; chemoradiotherapy; preoperative chemotherapy; PATHOLOGICAL COMPLETE RESPONSE; TUMOR-REGRESSION; RADIOTHERAPY; CHEMORADIATION; RADIOCHEMOTHERAPY; FLUOROURACIL; RECURRENCE; IRINOTECAN; THERAPY;

D O I：

10.1111/codi.13724

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AimThe aim was to determine whether the addition of additional cycles of chemotherapy during the 'wait period' following neoadjuvant chemoradiotherapy for rectal cancer improves the pathological complete response (pCR) rate. MethodRectal cancer patients were randomly allocated either to a standard 10week wait period before surgery (standard chemoradiotherapy, SCRT) or to receive three cycles of fluorouracil based chemotherapy following chemoradiotherapy during a similar 10week wait (extended chemoradiotherapy, XCRT). The primary end-point was pCR as determined by blinded pathological assessment. ResultsForty-nine patients were randomized (SCRTn=24, XCRTn=25). pCR occurred in 10 patients overall but there was no significant difference in pCR between the groups (SCRTn=6, XCRTn=4, P=0.49). ConclusionThe addition of three cycles of 5-fluorouracil/leucovorin in a 10week wait period after conventional chemoradiotherapy seems to result in similar pCR rates in patients with locally advanced rectal cancer based on this small randomized trial.

引用

页码：973 / 979

页数：7

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