VDUP1 is required for the development of natural killer cells

被引：124

作者：

Lee, KN

Kang, HS

Jeon, JH

Kim, EM

Yoon, SR

Song, H

Lyu, CY

Piao, ZH

Kim, SU

Han, YH

Song, SS

Lee, YH

Song, KS

Kim, YM

Yu, DY ^{[1
]}

Choi, I

机构：

[1] Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea

[2] Chonnam Natl Univ, Sch Biol Sci & Technol, Biotechnol Res Inst, Kwangju 500757, South Korea

[3] Korea Res Inst Biosci & Biotechnol, Lab Dev & Differentiat, Taejon 305333, South Korea

[4] Chungnam Natl Univ, Coll Med, Dept Anat, Taejon 301131, South Korea

[5] Chungnam Natl Univ, Coll Med, Dept Pathol, Taejon 301131, South Korea

来源：

IMMUNITY | 2005年 / 22卷 / 02期

关键词：

D O I：

10.1016/j.immuni.2004.12.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vitamin D-3 upregulated protein 1 (VDUP1) is a stress-response gene that is upregulated by 1,25(OH)(2)D-3 in tumor cells. The in vivo roles of VDUP1 were investigated by producing mice lacking VDUP1 (VDUP1(-/-) mice). VDUP1(-/-) mice showed minimal changes in the development of T and B cells, but there was a profound reduction in the numbers of natural killer (NK) cells. As well, these mice showed decreased NK activity. In the VDUP1(-/-) mice, the expression of CD122 was reduced, demonstrating that VDUP1 is required for CD122 expression and NK maturation. In addition, severe lymphoid hyperplasia in the small intestine was observed in VDUP1(-/-) mice. Taken together, these results suggest that VDUP1 is a critical factor for the development and function of NK cells in vivo.

引用

页码：195 / 208

页数：14

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