Dysregulation of E-cadherin in chronic rhinosinusitis with nasal polyps

被引：2

作者：

Kong, Weijia ^{[1
]}

Wu, Junhua ^{[1
,2
]}

Wang, Yanjun ^{[1
]}

Yue, Jianxin ^{[1
]}

Zhang, Song ^{[1
]}

Yu, Yanping ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Otorhinolaryngol, Wuhan 430022, Peoples R China

[2] Xiamen Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, Xiamen 361003, Peoples R China

来源：

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES | 2010年 / 30卷 / 04期

关键词：

E-cadherin; chronic rhinosinusitis; nasal polyps;

D O I：

10.1007/s11596-010-0459-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

E-cadherin is a key epithelial protein and adhesive molecule. This study detected the E-cadherin expression in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and controls, and analyzed its possible role in the pathogenesis of CRSwNP. The expression of E-cadherin was detected by using Western blotting and immunohistochemistry in controls and patients with CRSwNP. Computed tomography (CT) scan findings were scored. The results showed that the E-cadherin expression was up-regulated in patients with CRSwNP as compared with controls (P=0.039) and the positive staining was predominantly localized on the epithelial cell membrane. E-cadherin level was correlated negatively with Lund-Mackay scores in patients with CRSwNP (r=-0.604, P=0.005). It is suggested that E-cadherin may be involved in the pathogenesis of CRSwNP and correlated with disease severity.

引用

页码：509 / 513

页数：5

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