Synthesis of modified purine nucleosides and related compounds mediated by adenosine deaminase (ADA) and adenylate deaminase (AMPDA)

被引：26
作者：
Santaniello, E [1 ]
Ciuffreda, P [1 ]
Alessandrini, L [1 ]
机构：
[1] Univ Milan, Dipartimento Sci Preclin LITA Vialba, I-20157 Milan, Italy
来源：
SYNTHESIS-STUTTGART | 2005年 / 04期
关键词：
adenosine deaminase; adenylate deaminase; nucleosides; carbocyclonucleosides; acyclonucleosides;
D O I：
10.1055/s-2005-861821
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Adenosine deaminase (ADA) and adenylic acid deaminase (AMPDA) are enzymes that catalyze the hydrolytic deamination of various purine nucleosides. In light of recent reports, ADA and AMPDA may be considered as valuable biocatalysts in nucleoside chemistry. Here, they can find many synthetic applications in the transformation of purine nucleosides that are modified in the base or the ribose moiety. Their use can be extended to carbocyclonucleosides or acyclonucleosides as well.
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收藏
页码：509 / 526
页数：18
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