Anti-lipidaemic and anti-inflammatory effect of acai (Euterpe oleracea Martius) polyphenols on 3T3-L1 adipocytes

被引：31
作者：
Duarte Martino, Hercia Stampini [1 ,2 ]
dos Santos Dias, Manoela Maciel [1 ,3 ]
Noratto, Giuliana [1 ]
Talcott, Stephen [1 ]
Mertens-Talcott, Susanne U. [1 ]
机构：
[1] Texas A&M Univ, Dept Nutr & Food Sci, College Stn, TX USA
[2] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil
[3] Univ Fed Vicosa, Dept Food Technol, Vicosa, MG, Brazil
来源：
JOURNAL OF FUNCTIONAL FOODS | 2016年 / 23卷
关键词：
Adipocyte differentiation; Adipogenesis; Intracellular lipids; Inflammatory biomarkers; Transcription factors; Oxidative stress; NF-KAPPA-B; MITOTIC CLONAL EXPANSION; ADIPOSE-TISSUE; TRANSCRIPTIONAL CONTROL; IMMUNE-RESPONSE; BINDING PROTEIN; PLASMA-PROTEIN; FATTY-ACIDS; INFLAMMATION; OBESITY;
D O I：
10.1016/j.jff.2016.02.037
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The anti-lipidaemic and anti-inflammatory effects of acai polyphenols in 3T3-L1 mouse adipocytes were investigated. Pre-adipocytes were differentiated with and without acai-polyphenols at concentrations of 2.5, 5 and 10 mu g gallic acid equivalents (GAE)/mL. Results showed that acai polyphenols reduce the accumulation of intracellular lipids in differentiated adipocytes in a dose-dependent manner and downregulated PPAR gamma 2. The gene expression of adipogenic transcription factors C/ebp alpha, C/ebp beta, Klf5 and Srebp1c was decreased. This was accompanied by a reduction of adipogenic genes, including aP2, LPL, FATP1 and FAS, leptin and total PAI and an increase of adiponectin. Additionally, acai polyphenols protected cells against the production of ROS and decreased the expression of mRNA and protein levels of pro-inflammatory cytokines when 3T3-L1 cells were challenged with TNF-alpha. Thus, these results indicate that acai polyphenols may be useful in the prevention of adipogenesis, oxidative stress and inflammation. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：432 / 443
页数：12
相关论文
共 59 条
  • [31] Obesity, Inflammation and Diet
    Lee, Hansongyi
    Lee, In Seok
    Choue, Ryowon
    [J]. PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION, 2013, 16 (03) : 143 - 152
  • [32] Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 Diabetes
    Lee, Jongsoon
    [J]. ARCHIVES OF PHARMACAL RESEARCH, 2013, 36 (02) : 208 - 222
  • [33] The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity -: Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor γ and IκB kinase activities
    Makowski, L
    Brittingham, KC
    Reynolds, JM
    Suttles, J
    Hotamisligil, GKS
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (13) : 12888 - 12895
  • [34] Inhibitory effects of Euterpe oleracea Mart. on nitric oxide production and iNOS expression
    Matheus, Maria Eline
    de Oliveira Fernandes, Sidnei Bessa
    Silveira, Cristiane Silva
    Rodrigues, Veronica Pinto
    Menezes, Fabio de Sousa
    Fernandes, Patricia Dias
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2006, 107 (02) : 291 - 296
  • [35] Betulinic Acid Decreases ER-Negative Breast Cancer Cell Growth In Vitro and In Vivo: Role of Sp Transcription Factors and MicroRNA-27a:ZBTB10
    Mertens-Talcott, Susanne U.
    Noratto, Giuliana D.
    Li, Xiangrong
    Angel-Morales, Gabriela
    Bertoldi, Michele C.
    Safe, Stephen
    [J]. MOLECULAR CARCINOGENESIS, 2013, 52 (08) : 591 - 602
  • [36] The impact of obesity on the immune response to infection
    Milner, J. Justin
    Beck, Melinda A.
    [J]. PROCEEDINGS OF THE NUTRITION SOCIETY, 2012, 71 (02) : 298 - 306
  • [37] Long chain acyl CoA synthetase 1 and gelsolin are oppositely regulated in adipogenesis and lipogenesis
    Mukherjee, Rajib
    Yun, Jong Won
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 420 (03) : 588 - 593
  • [38] Polyphenolics from Acai (Euterpe oleracea Mart.) and Red Muscadine Grape (Vitis rotundifolia) Protect Human Umbilical Vascular Endothelial Cells (HUVEC) from Glucose- and Lipopolysaccharide (LPS)-Induced Inflammation and Target MicroRNA-126
    Noratto, Giuliana D.
    Angel-Morales, Gabriela
    Talcott, Stephen T.
    Mertens-Talcott, Susanne U.
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 59 (14) : 7999 - 8012
  • [39] Flavonol-rich fractions of yaupon holly leaves (Ilex vomitoria, Aquifoliaceae) induce microRNA-146a and have anti-inflammatory and chemopreventive effects in intestinal myofribroblast CCD-18Co cells
    Noratto, Giuliana D.
    Kim, Youngmok
    Talcott, Stephen T.
    Mertens-Talcott, Susanne U.
    [J]. FITOTERAPIA, 2011, 82 (04) : 557 - 569
  • [40] Obesity: An emerging disease
    Ogunbode, A. M.
    Ladipo, M. M. A.
    Ajayi, I. O.
    Fatiregun, A. A.
    [J]. NIGERIAN JOURNAL OF CLINICAL PRACTICE, 2011, 14 (04) : 390 - 394
123456