Assessment of spontaneous fluctuations of viral load in untreated patients with chronic hepatitis C by two standardized quantitation methods:: Branched DNA and Amplicor monitor

被引：27
作者：
Halfon, P
Bourlière, M
Halimi, G
Khiri, H
Bertezene, P
Portal, I
Bota-Fridlund, D
Gauthier, AP
Jullien, M
Feryn, JM
Gerolami, V
Cartouzou, G
机构：
[1] Hop Concept, Alphabio Lab, Marseille, France
[2] Hop Concept, Dept Biochem, Marseille, France
[3] Hop Concept, Dept Hepatogastroenterol, Marseille, France
[4] Hop St Joseph, Dept Hepatogastroenterol, Marseille, France
[5] INSERM, U315, F-13258 Marseille, France
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 1998年 / 36卷 / 07期
关键词：
D O I：
10.1128/JCM.36.7.2073-2075.1998
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Quantitation of hepatitis C virus (HCV) RNA in serum has been used to predict and monitor the efficacy of interferon therapy in chronic HCV infection. We prospectively studied the fluctuation of viremia by a longitudinal follow-up of HCV RNA levels for 2 months in six untreated patients. Spontaneous fluctuations of HCV RNA ranged from 2.8- to 5.7-fold with branched DNA assay and from 2.9- to 5.6-fold with Monitor. These large spontaneous fluctuations (up to 0.75 log), observed daily, weekly, and monthly, raise doubt about the clinical value of a single assessment of pretherapeutic viremia.
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页码：2073 / 2075
页数：3
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