Research Progress on The Mechanism and Treatment of Inflammatory Response in Myocardial Ischemia-Reperfusion Injury

被引：20

作者：

Zhang, Dong ^{[1
,2
]}

Wu, Hui ^{[1
]}

Liu, Di ^{[2
]}

Li, Yun Zhao ^{[1
,2
]}

Zhou, Gang ^{[1
,2
]}

机构：

[1] China Three Gorges Univ, Coll Clin Med Sci 1, Dept Cardiol, Yiling Rd 183, Yichang 443000, Hubei, Peoples R China

[2] China Three Gorges Univ, Inst Cardiovasc Dis, Yichang 443000, Peoples R China

来源：

HEART SURGERY FORUM | 2022年 / 25卷 / 03期

基金：

中国国家自然科学基金;

关键词：

MITOCHONDRIAL QUALITY-CONTROL; CASPASE INHIBITION; ACTIVATION; RECEPTORS; PROTECTS; TARGETS;

D O I：

10.1532/hsf.4725

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute myocardial infarction can be treated aggressively with intravenous thrombolysis, percutaneous coronary intervention, and coronary artery bypass grafting; however, recanalization can cause myocardial ischemia-reperfusion injury (MIRI). This is an important reason that restricts the treatment effect of patients. After the ischemic myocardium is restored to perfusion, an inflammatory response can occur within minutes and peak within a few days. Many pro -inflam-matory cytokines can seriously damage cardiac function. Inflammation can regulate cardiomyocyte apoptosis, autoph-agy, pyroptosis, and necrosis, and is the main initiating factor leading to MIRI in cardiomyocytes. This article reviews the mechanism of inflammatory response in the ischemia-reperfusion period after acute myo-cardial infarction and the clinical value and application pros-pect of inhibiting inflammatory response in the treatment of acute myocardial infarction.

引用

页码：E462 / E468

页数：7

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