DNA methylation inhibitors: Retrospective and perspective view

被引：20

作者：

Uddin, Md Gias ^{[1
,2
]}

Fandy, Tamer E. ^{[1
]}

机构：

[1] Univ Charleston, Sch Pharm, Dept Pharmaceut & Adm Sci, Charleston, WV 29403 USA

[2] Appalachian Coll Pharm, Dept Pharmaceut Sci, Oakwood, VA 24631 USA

来源：

ADVANCES IN CANCER RESEARCH, VOL 152 | 2021年 / 152卷

关键词：

CATECHOL-O-METHYLTRANSFERASE; TUMOR-SUPPRESSOR GENES; GREEN TEA POLYPHENOLS; DE-NOVO METHYLATION; HISTONE DEACETYLASE; SILENCED GENES; CANCER CELLS; PHASE-I; 5-AZACYTIDINE; REACTIVATION;

D O I：

10.1016/bs.acr.2021.03.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA methylation is an epigenetic modification that contributes to essential biological processes such as retrotransposon silencing, cell differentiation, genomic imprinting and X-chromosome inactivation. DNA methylation generates a stable epigenetic mark associated with silencing of gene expression. Aberrant DNA methylation is associated with the development of different tumor types. Reversing DNA methylation is a rational strategy to restore gene re-expression and induce cell differentiation in cancer. DNA hypomethylating agents is a class of drugs that demonstrated efficacy in different tumors. In this chapter, the classification of DNA hypomethylating agents, their pharmacodynamics and their potential drawbacks will be discussed.

引用

页码：205 / 223

页数：19

共 50 条

[1] DNA methylation: a historical perspective
Mattei, Alexandra L.
Bailly, Nina
Meissner, Alexander
TRENDS IN GENETICS, 2022, 38 (07) : 676 - 707
[2] New cytosine derivatives as inhibitors of DNA methylation
Plitta, Beata
Adamska, Ewelina
Giel-Pietraszuk, Malgorzata
Fedoruk-Wyszomirska, Agnieszka
Naskret-Barciszewska, Miroslawa
Markiewicz, Wojciech T.
Barciszewski, Jan
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 : 243 - 254
[3] Development of DNA Methyltransferase Inhibitors for the Treatment of Neoplastic Diseases
Fandy, Tamer E.
CURRENT MEDICINAL CHEMISTRY, 2009, 16 (17) : 2075 - 2085
[4] New insights on the role of DNA methylation from a global view
Meier, Karin
Recillas-Targa, Felix
FRONTIERS IN BIOSCIENCE-LANDMARK, 2017, 22 : 644 - 668
[5] DNA methylation in an engineered heart tissue model of cardiac hypertrophy: common signatures and effects of DNA methylation inhibitors
Stenzig, Justus
Hirt, Marc N.
Loeser, Alexandra
Bartholdt, Lena M.
Hensel, Jan-Tobias
Werner, Tessa R.
Riemenschneider, Mona
Indenbirken, Daniela
Guenther, Thomas
Mueller, Christian
Huebner, Norbert
Stoll, Monika
Eschenhagen, Thomas
BASIC RESEARCH IN CARDIOLOGY, 2016, 111 (01) : 1 - 14
[6] DNA methylation in cell differentiation and reprogramming: an emerging systematic view
Huang, Kevin
Fan, Guoping
REGENERATIVE MEDICINE, 2010, 5 (04) : 531 - 544
[7] Identification of novel DNA methylation inhibitors via a two-component reporter gene system
Lin, Yi-Shiuan
Shaw, Arthur Y.
Wang, Shi-Gang
Hsu, Chia-Chen
Teng, I-Wen
Tseng, Min-Jen
Huang, Tim H. M.
Chen, Ching-Shih
Leu, Yu-Wei
Hsiao, Shu-Huei
JOURNAL OF BIOMEDICAL SCIENCE, 2011, 18
[8] Pattern of DNA Methylation in Daphnia : Evolutionary Perspective
Kvist, Jouni
Athanasio, Camila Goncalves
Solari, Omid Shams
Brown, James B.
Colbourne, John K.
Pfrender, Michael E.
Mirbahai, Leda
GENOME BIOLOGY AND EVOLUTION, 2018, 10 (08): : 1988 - 2007
[9] Inhibitors of DNA Methylation and Histone Deacetylation as Epigenetically Active Drugs for Anticancer Therapy
Myasoedova, Veronika A.
Sulchorukov, Vasily
Grechko, Andrey, V
Zhang, Dongwei
Romanenko, Elena
Orekhov, Vawain
Orekhov, Alexander N.
CURRENT PHARMACEUTICAL DESIGN, 2019, 25 (06) : 635 - 641
[10] Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS
Leone, G
Vosoa, MT
Teofili, L
Lübbert, M
CLINICAL IMMUNOLOGY, 2003, 109 (01) : 89 - 102

← 1 2 3 4 5 →